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New trial aims to stop phantom limb pain before it starts

NCT ID NCT07139483

Prevention Sponsor: University of Haifa Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether combining mirror therapy with a gentle brain stimulation technique (tDCS) soon after amputation can prevent phantom limb pain from becoming a long-term problem. 108 recent amputees will be split into three groups: one gets mirror therapy plus real tDCS, one gets mirror therapy plus fake tDCS, and one gets no extra treatment. The goal is to see if the combo can stop pain from sticking around.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transcranial direct current stimulation (tDCS) device
What this could lead to
If it works, this could point toward a way to stop phantom limb pain from becoming chronic after amputation.
What could go wrong
This is an early-stage study with only 108 participants, so results may not apply to everyone. The combined therapy may not work better than mirror therapy alone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 108 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2025

Expected to finish

Mar 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults (age ≥18); * Amputation of a single limb ≤12 weeks ago; during this period of time, 80% of amputees develop PLP. Both upper and lower limb amputees are included to increase feasibility; * Acute PLP stage (2 weeks since first report), with intensity ≥3 on a 0-10 VAS; * No change in medication in past week, excluding pro re nata analgesics; * Can understand the study's purpose and instructions; * Agrees to participate and to provide written informed consent. Exclusion Criteria: * Stump wound not healed; * Other psychological, psychiatric, or neurological conditions; * Contraindications for tDCS or magnetic resonance imaging (MRI) (MRI data will not be analyzed in the proposed PhD project), including previous seizure, loss of consciousness due to head injury, metal in the head, implanted devices, claustrophobia, a skin condition or an unhealed wound on the scalp, and possibility of being pregnant; * Inability to provide informed consent or understand or carry out the experiment.

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Conditions

The condition(s) this trial relates to.

Phantom Limb

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Phantom limb pain after amputation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    3 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Loewenstein Hospital

    RECRUITING

    Raanana, Israel, Ahuza 278, Israel

  • Reut Medical Center

    RECRUITING

    Tel Aviv, Israel, Israel

  • Sheba Medical Center

    NOT_YET_RECRUITING

    Tel Aviv, Israel

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