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Can skipping opioids speed up recovery from thyroid surgery?

NCT ID NCT05577962

Symptom relief Sponsor: Beijing Friendship Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time

Summary

This trial tests whether an opioid-free anesthesia approach can improve early recovery quality after thyroidectomy compared to traditional balanced anesthesia. Adults undergoing elective thyroid surgery will be randomly assigned to receive either the opioid-free protocol or standard care. The main goal is to compare recovery scores, pain levels, and complication rates in the first days after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Opioid-free anesthesia protocol using dexamethasone, flurbiprofen axetil, dexmedetomidine, lidocaine, esketamine, propofol, and rocuronium
What this could lead to
If successful, this approach could offer a safer, more comfortable recovery from thyroid surgery without the side effects of opioids.
What could go wrong
This is a single-center trial with 160 participants, so results may not apply broadly. The opioid-free regimen may not control pain as effectively for everyone, and there are risks from the alternative drugs used.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 160 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2024

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 99 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * Patients undergoing elective thyroidectomy under general anesthesia * \>18 year old * The informed consent form has been signed * American Society of Anesthesiologists (ASA) anesthesia grade I - II Exclusion Criteria: * Long term use of opioids * Long term use of NSAIDs * Have a history of psychosis, epilepsy, preoperative anxiety, depression, and emotional management disorders * Patients with increased gastric contents reflux and respiratory tract aspiration * Operation time\>3h * Severe liver and kidney insufficiency, cardiac insufficiency, bradycardia with 2 ° II or 3° atrioventricular block * Those who are allergic to or have contraindications to drugs that may be used in the test * Those who cannot cooperate with researchers

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Opioid-free anesthesia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Beijing Friendship Hospital, Capital Medical University

    RECRUITING

    Beijing, Beijing Municipality, 100050, China

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