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Wrinkle-Free wonder? small study tests microtox for skin smoothness

NCT ID NCT06604832

Symptom relief Sponsor: Kalpna Kay Durairaj, MD, FACS Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed Phase 1 trial tested whether injecting a botulinum toxin (prabotulinumtoxinA-xvfs, also known as Jeuveau) into the forehead can improve facial skin quality, fine wrinkles, and texture. Twenty women with mild to moderate wrinkles received the treatment on one side of their face and either a placebo or a different toxin on the other side. Doctors rated skin changes using a scientific scale and an aesthetic improvement scale over 12 weeks.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
PrabotulinumtoxinA-xvfs (Jeuveau)
What this could lead to
If it works, this could point toward a cosmetic treatment for fine wrinkles and skin texture improvement.
What could go wrong
This is a very small, early-phase trial with only 20 participants, so results may not apply to everyone. The study is also completed, so no further development is planned.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

20 people

The number who actually took part.

Started

Sep 2024

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Biological females, 18-65 years old, of any race and ethnic background * Individuals with mild to moderate facial wrinkles * All skin types (Fitzpatrick I-VI) * Willingness to participate and provide written informed consent * Ability to follow study instructions and likely to complete all required visits Exclusion Criteria: * Females who are pregnant, breastfeeding, chronically using nonsteroidal anti-inflammatory drugs, have autoimmune conditions or have a known allergy to the study medications. * Previous cosmetic procedures near the forehead within the last 6 months or botulinum toxin treatments within the last 4 months * Known neuromuscular disorders or a hypersensitivity to botulinum toxin * Significant dermatological conditions affecting the face * Use of medications affecting neuromuscular function or skin healing within 2 weeks prior to the beginning of study * Subject has a condition or is in a situation which, in the opinion of the Investigator, may put the subject at significant risk, may confound the study results, or may interfere significantly with participation in the study.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Skin aging Skin wrinkling

Contacts and locations

Locations

  • K. Kay Durairaj, MD, A Medical Corp.

    Pasadena, California, 91105, United States

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