Can a daily supplement turn back the clock on aging skin?
NCT ID NCT07740824
First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time
Summary
This study tests whether two oral nutritional supplements can improve skin health and reduce signs of aging in healthy adults aged 35 to 65. Participants take the supplements or a placebo daily for 8 weeks, with skin biopsies and imaging used to measure changes in aging markers. The goal is to see if these 'beauty from within' products can visibly and biologically improve skin.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- oral skin health supplement (softgel and powder formulations)
- What this could lead to
- If successful, this could point toward a convenient daily supplement to reduce visible signs of skin aging and improve skin health from within.
- What could go wrong
- The trial is small (90 participants) and early, so results may not apply broadly. Supplements often show modest effects, and skin changes may be subtle or not noticeable.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 90 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Aug 2026
An estimate. Start dates often move.
- Expected to finish
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Aug 2027
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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35 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Male and female trial participants in the age group of 35 -65 years, both ages inclusive. 2. Trial participants in good general health, as determined by the Investigator based on medical history, physical examination, vital signs, and clinical laboratory evaluations (CBC, LFT, and RFT). 3. Trial participants presenting with visible signs of facial skin aging, as assessed by the Investigator. 4. Trial participants willing to consume the assigned study products daily for 8 weeks in accordance with the study protocol. 5. Trial participants must be willing to undergo two minimally invasive skin biopsies collected from the upper arms. 6. Trial participants must be willing to provide blood samples for plasma collection and laboratory Investigations. 7. Trial participants willing to refrain from initiating any new skin care products, oral supplements, or anti-aging treatments during the study. 8. Trial participants willing to maintain their permitted and restricted skincare, diet, and lifestyle habits throughout the study. 9. Trial participants free of excessive hair, acne, cuts, abrasions, fissures, wounds, lacerations, or any other active skin conditions on the face and upper arms as determined by the dermatologist. 10. Trial participants who agree not to have direct and excessive sun exposure (not more than half an hour daily and during that time use of umbrella to cover face and upper arms). 11. Trial participants willing to refrain from bleaching or any other procedures including facial etc. on face during the study period. 12. Trial participants willing to give a voluntary written informed consent, photography release and agree to come for regular follow-up. 13. Trial participants willing to abide by and comply with study protocol. Exclusion Criteria: 1. Trial participants with known allergy, hypersensitivity, or intolerance to the study products or any of their ingredients, which, in the opinion of the Investigator, may impact participant safety, skin condition, or study outcomes. 2. Trial participants with clinical non-significant laboratory values or clinically significant findings in CBC, LFT, or RFT that, in the opinion of the Investigator, may affect participant safety or study participation. 3. Trial participants with a history or presence of clinically significant systemic diseases, including cardiovascular, immunological, vascular, hepatic, gallbladder, renal, or other uncontrolled medical disorders that, in the opinion of the Investigator, may interfere with study participation or study assessments. 4. Trial participants with active dermatological conditions on the face, including eczema, psoriasis, rosacea, acne, dermatitis, infections, wounds, sunburn, scars, or other skin disorders that may interfere with study assessments. 5. Trial participants who have used anti-aging treatments or procedures, including retinoids, isotretinoin, topical, systemic, injectable, or device-based therapies, within 3 months prior to screening. 6. Trial participants currently taking any medication that, in the opinion of the Investigator, may affect study results or interfere with study participation. 7. Trial participants who have undergone facial cosmetic procedures or aesthetic treatments, including chemical peels, laser treatments, dermabrasion, microneedling, botulinum toxin injections, dermal fillers, or similar procedures within 3 months prior to screening. 8. Trial participants currently using or having used within 1 month prior to screening oral supplements or medications known to influence skin appearance or aging (e.g., collagen supplements, biotin, antioxidant supplements, or investigational products). 9. Trial participants with a history of keloid formation, hypertrophic scarring, poor wound healing, bleeding disorders, or active skin infection, inflammation, wounds, or other abnormal skin conditions at or near the planned biopsy site. 10. Trial participants with a known bleeding disorder or current use of anticoagulant/antiplatelet medications that may interfere with blood collection. 11. Trial participants who have participated in another similar clinical trial within 3 months prior to screening. 12. Female trial participants who are pregnant, breastfeeding, or planning pregnancy during the study period. 13. Trial participants with a history of smoking, current smoking, use of smokeless tobacco products, or a history of or ongoing alcohol or recreational drug abuse. 14. Trial participants who are employees of the Sponsor, Contract Research Organization (CRO), or study site directly involved in the conduct of the study. 15. Trial participants judged by the Investigator to be unsuitable for participation for any reason that may compromise participant safety, protocol compliance, or study integrity.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
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