Light and peel combo may turn back the clock on aging hands
NCT ID NCT04485091
First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time
Summary
This trial tests whether combining a 20% trichloroacetic acid (TCA) chemical peel with LED light therapy (photobiomodulation) can improve signs of sun damage on the hands better than the peel alone. Forty-two adults with mild-to-moderate skin aging will receive four monthly treatments. Researchers will compare changes in fine wrinkles, coarse wrinkles, and skin discoloration using standardized photos and expert ratings.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- a combination of 20% trichloroacetic acid (TCA) chemical peel and 660nm LED photobiomodulation (PBM) light therapy
- What this could lead to
- If the combination works better than the peel alone, it could offer a more effective, non-surgical option for rejuvenating sun-damaged skin on the hands.
- What could go wrong
- This is a small, early-phase trial with only 42 participants, so results may not apply to everyone. The treatment involves a chemical peel, which can cause pain, redness, and peeling.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
-
42 people
The number who actually took part.
- Started
-
Oct 2021
- Finished
-
Feb 2022
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
40 to 70 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Individuals without comorbidities or with controlled comorbidities (ASA I and ASA II physical status classification). * Participants must also have skin phototype I, II or III according to the Fitzpatrick classification. Exclusion Criteria: * Smoking, alcoholic, oncological, malnourished, anemic, pregnant, immunosuppressed participants. * Patients with blood dyscrasias, psychiatric illnesses, collagen diseases (even with proper control), photosensitivity, individuals undergoing chemotherapy or hormone therapy and with scar changes (keloids and hypertrophic scar). * Also excluded from the study are individuals who performed previous aesthetic procedures on their hands and use of medications that influence skin color, such as amiodarone, tetracyclines, tricyclic antidepressants, phenothiazines and others.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Nove de Julho (UNINOVE)
São Paulo, 01504-001, Brazil
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