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Microbubbles may replace needles for heart pressure checks

NCT ID NCT07416279

Diagnosis Sponsor: King's College London Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether ultrasound contrast agents (microbubbles) can estimate pressure inside the heart, potentially replacing invasive catheters. Ten adults with suspected heart disease will receive a standard ultrasound with contrast while also having a catheter for comparison. The goal is to see if the microbubble signal matches catheter readings and can be calibrated to measure pressure.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
SonoVue (ultrasound contrast agent)
What this could lead to
If successful, this could lead to a non-invasive way to measure heart pressure using ultrasound, reducing the need for catheter procedures.
What could go wrong
This is a very early, small study with only 10 participants. The technique may not be accurate enough to replace catheters, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 10 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Feb 2026

An estimate. Start dates often move.

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 81 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participant is willing and able to give informed consent to participate in the study * Patients who require a cardiac catheterisation procedure as part of their standard medical care * Good acoustic windows for echocardiography when lying flat on their back Exclusion Criteria: * Known previous allergy to SonoVue, used in ultrasound contrast scans * Known allergy to any of the components of SonoVue microbubbles, for example, sulphur hexafluoride or polyethylene glycol (PEG), also known as macrogol, which is in bowel preparations used during colonoscopy and certain laxatives * A hole in their heart that lets blood flow from the right side to the left, skipping the lungs * Very high blood pressure in the arteries of the lungs (severe pulmonary hypertension) * Uncontrolled high blood pressure (hypertension) * Adult respiratory distress syndrome (ARDS; where severe lung inflammation prevents enough oxygen from reaching the body) * Current use of the medicine dobutamine (used to treat heart failure), or have been advised not to take dobutamine * Moderate to severe heart valve disease that could affect the catheter measurements * Recent acute coronary syndrome or unstable ischaemic cardiac disease, where blood flow to the heart muscle is reduced * Pregnant or may be pregnant * Participation in a clinical trial of a medicine within the past four months, to avoid any possible interactions with SonoVue * Participating in other research that would prolong their cardiac catheterisation procedure, to ensure that the overall process does not become too tiring or burdensome

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Conditions

The condition(s) this trial relates to.

diastolic heart failure heart disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiac catheterisation Heart disease Hfpef - heart failure with preserved ejection fraction

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • King's College Hospital

    RECRUITING

    London, SE5 9RS, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.