Could a simple mouthguard replace CPAP in a pinch?
NCT ID NCT05939934
First seen Apr 10, 2026 · Last updated Jun 23, 2026 · Updated 13 times
Summary
This study tests whether a custom mouthpiece (mandibular advancement device) can help people with obstructive sleep apnea when they temporarily stop using their CPAP machine. Forty adults who normally use CPAP will either use the mouthpiece or nothing during a two-week CPAP break. Researchers will measure changes in sleepiness, blood pressure, and heart function to see if the mouthpiece reduces the negative effects of stopping CPAP.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Angers University Hospital
RECRUITINGAngers, 49100, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
mandibular advancement device (MAD)
What this could lead to
If it works, this could offer a temporary backup option for sleep apnea patients who need to stop CPAP for a short time.
What could go wrong
This is a small, early-stage trial with only 40 participants. The MAD may not fully prevent symptom return or heart issues during CPAP withdrawal.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.