SLEEP APNEA, OBSTRUCTIVE

This study tests whether a custom mouthpiece (mandibular advancement device) can help people with obstructive sleep apnea when they temporarily stop using their CPAP machine. Forty adults who normally use CPAP will either use the mouthpiece or nothing during a two-week CPAP break…

This study tests a jaw surgery called maxillomandibular advancement for people with moderate to severe obstructive sleep apnea who cannot use standard treatments like CPAP machines. The surgery moves the jaw forward to open the airway, and researchers will track breathing, sleepi…

This study follows 20 people who have already used a flexible silicone tube device (NPA-OSA) for obstructive sleep apnea. Participants will continue using the device at night for up to 12 months. Researchers will check if the device keeps working well by measuring sleep apnea eve…

This study looks at whether using a CPAP machine at night can help lower high red blood cell levels (polycythemia) in people with moderate to severe sleep apnea. About 182 adults aged 18-80 with both conditions will be randomly assigned to use CPAP or not for one year. Researcher…

This study looks at whether a home sleep apnea test is as accurate as the standard overnight sleep lab test for children ages 5 to 12. Researchers will compare results from both tests and see how they affect treatment choices. The goal is to find a more comfortable and convenient…

This study is testing a new device that measures how sensitive the throat is to help diagnose obstructive sleep apnea (OSA). Researchers will compare the results of this test with standard sleep studies in 117 adults. The goal is to see if this simpler, quicker test can accuratel…

This study tests a once-weekly medicine called eloralintide in 800 adults with moderate-to-severe sleep apnea who are also overweight or have obesity. The goal is to see if it reduces breathing pauses during sleep and helps with weight loss. Some participants use a breathing mach…

This study compares two surgical approaches for children aged 3-17 having their tonsils removed. One group gets standard tonsillectomy, the other gets an extra procedure called lateral pharyngoplasty. Researchers want to see if the extra step leads to less pain, quicker return to…

This study tests a new device placed in the nose to treat obstructive sleep apnea in adults who cannot tolerate CPAP. About 20 participants will use the device for 30 days to see if it reduces breathing pauses during sleep. The goal is to offer an easier-to-use alternative for pe…

This early-phase study tests whether an oxytocin nose spray can lower the air pressure needed from a CPAP machine during sleep, potentially reducing side effects from low oxygen in people with obstructive sleep apnea. About 40 adults will take part over 35 nights, including three…

This study looks at people with obstructive sleep apnea who are considering a nerve stimulation device (Inspire) because they can't use CPAP. Researchers will measure airway changes during a routine sleep endoscopy to see if they can predict who will get good results from the dev…

This study tests a program called REPOSE that assigns a patient navigator to help families of children with sleep-disordered breathing. The navigator identifies barriers, provides resources, and coordinates care between doctors and parents. The goal is to see if this support help…

This study looks at how sleep apnea (pauses in breathing during sleep) affects blood sugar levels in adults with type 1 diabetes. Researchers will track blood sugar patterns using continuous glucose monitors in 40 participants. The goal is to understand the link between sleep apn…

This study follows 82 children aged 8 to 18 who have obstructive sleep apnea and are starting positive airway pressure (PAP) therapy. Researchers want to see if insomnia makes it harder for kids to use their PAP machines regularly, and whether race or ethnicity plays a role. The …

This study looks at whether breathing through the nose or mouth changes how the airway collapses in people with sleep apnea. About 50 adults will have a sleep endoscopy while lightly sedated. The goal is to see if the breathing route during the test matches natural sleep and affe…