Can a cold virus drug ease COPD Flare-Ups? new trial results are in

NCT ID NCT06149494

Completed Symptom relief Sponsor: Altesa Biosciences, Inc. Source: ClinicalTrials.gov ↗

First seen Oct 31, 2025 · Last updated Jun 15, 2026 · Updated 37 times

Summary

This study tested whether vapendavir, an experimental antiviral drug, could reduce lower respiratory symptoms (like cough, wheezing, and shortness of breath) in 52 adults with COPD who were deliberately exposed to a common cold virus (rhinovirus). The goal was to see if the drug could prevent or lessen the severity of COPD flare-ups triggered by the virus. The trial has been completed, and the results will show how well vapendavir worked compared to a placebo.

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Contacts and locations

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Locations

St. Mary's Hospital - Imperial College Respiratory Research Unit (ICRRU)

London, W2 1NY, United Kingdom

Conditions

The condition(s) this trial relates to.

chronic obstructive pulmonary disease common cold enterovirus infectious disease Infections infectious disease lung disorder obstructive lung disease pulmonary emphysema Respiration Disorders respiratory system disorder respiratory tract infectious disorder RNA Virus Infections viral infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC LOWER RESPIRATORY DISEASES CHRONIC RESPIRATORY DISEASE COPD COPD EXACERBATION ACUTE COPD WITH ACUTE LOWER RESPIRATORY INFECTION EMPHYSEMA OR COPD ENTEROVIRUS ENTEROVIRUS INFECTIONS INFECTION VIRAL INFECTION VIRAL INFECTIONS INFECTIONS INFECTIONS, RESPIRATORY INFECTIONS, RESPIRATORY LOWER RESPIRATORY DISEASE LOWER RESPIRATORY DISEASE LOWER RESPIRATORY DISORDER LOWER RESPIRATORY DISORDER LOWER RESPIRATORY TRACT AND LUNG INFECTIONS LOWER RESPIRATORY TRACT AND LUNG INFECTIONS LUNG DISEASE CHRONIC LUNG DISEASES OBSTRUCTIVE PULMONARY DISEASE PULMONARY DISEASE PULMONARY DISEASE, CHRONIC OBSTRUCTIVE RESPIRATORY COMPLICATION RESPIRATORY DISEASE RESPIRATORY DISEASE CHRONIC RESPIRATORY TRACT DISEASES RESPIRATORY TRACT INFECTIONS RESPIRATORY TRACT INFECTIONS RESPIRATORY VIRAL INFECTION RHINOVIRUS RHINOVIRUS INFECTION UPPER RESP TRACT INFECTION UPPER RESP TRACT INFECTION UPPER RESPIRATORY DISEASE UPPER RESPIRATORY DISEASE, ACUTE UPPER RESPIRATORY DISORDER UPPER RESPIRATORY INFECTION VIRAL UPPER RESPIRATORY TRACT INFECTIONS VIRAL INFECTION VIRUS DISEASES VIRUS INFECTION, RNA