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Brain training vs. puzzles: which boosts Alzheimer's Patients' minds?

NCT ID NCT07041008

Symptom relief Sponsor: Rsocialform - Geriatria, Lda Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested two types of mental exercises in 514 older adults with mild to moderate Alzheimer's disease. One group used a computer program with brain games, while the other used physical puzzles and memory cards. The goal was to see if these activities could improve thinking, memory, mood, and quality of life. The study also looked at whether the type of care facility or location made a difference.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
cognitive stimulation (digital software or physical materials)
What this could lead to
If it works, this could point toward simple, non-drug activities that help people with Alzheimer's maintain their thinking skills and mood.
What could go wrong
This is a completed study, but the results may not apply to everyone with Alzheimer's. The exercises are not a cure and may only offer modest, temporary benefits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

514 people

The number who actually took part.

Started

Sep 2025

Finished

Mar 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 65 or older. * Receive care/support services for at least three months. * A diagnosis of probable AD according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders, fifth edition, text revision. * Preserved communication skills. * Native Portuguese speaker. * Total scores between 10 and 26 points on the Mini Mental State Examination. Exclusion Criteria: * Cannot read and write. * Significant sensory or physical limitations. * Acute or chronic illness preventing participation. * Severe communication impairment. * Aggressive or disruptive behaviour. * Recent initiation (within two months) of neuroleptics, antipsychotics, or other psychoactive medications.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease anxiety disorder cognitive disorder Cognitive Dysfunction dementia Depression

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cognitive decline Cognitive dysfunction Cognitive impairment Dementia Neurocognitive disorders

Contacts and locations

Locations

  • AMITEI

    Leiria, Leria, Portugal

  • Associação Alzheimer Açores

    Açores, Portugal

  • Associação Casapiana de Solidariedade

    Lisbon, Portugal

  • Associação Cultural Recreativa e Social de Samuel

    Coimbra, Portugal

  • Associação de Desenvolvimento Comunitário do Funchal - Garouta do Calhau

    Funchal, Madeira, Portugal

  • Associação de Socorros da Freguesia de Turcifal

    Lisbon, Portugal

  • Associação de Solidariedade Social do Alto Paiva

    Viseu, Portugal

  • Associação de Solidariedade Social e Recreativa de Nespereira

    Viseu, Portugal

  • CASTIIS

    Aveiro, Portugal

  • CEDIARA - Associação de Solidariedade Social de Ribeira de Fráguas

    Aveiro, Portugal

  • Centro Apoio Social Mozelos

    Aveiro, Portugal

  • Centro Social Paroquial de Moita dos Ferreiros

    Lisbon, Portugal

  • Centro Social da Freguesia de Casal Comba

    Aveiro, Portugal

  • Centro Social do Vale do Homem Casa da Alegria

    Braga, Portugal

  • Fundação João Bento Raimundo

    Guarda, Portugal

  • Instituto S. João de Deus Funchal

    Funchal, Madeira, Portugal

  • O Jardim - Centro de Solidariedade Social de Canedo

    Aveiro, Portugal

  • Patronato de Santo António - Lar D. José do Patrocínio Dias

    Beja, Portugal

  • Quinta de Santa Ana RS

    Viana do Castelo, Portugal

  • Residência Sénior DON ANTÓNIO - Hilário & Pereira

    Castelo Branco, Portugal

  • Santa Casa da Misericórdia da Horta

    Açores, Portugal

  • Santa Casa da Misericórdia da Soalheira

    Castelo Branco, Portugal

  • Santa Casa da Misericórdia de Alcobaça

    Leiria, Portugal

  • Santa Casa da Misericórdia de Alvaiázere

    Leiria, Portugal

  • Santa Casa da Misericórdia de Alvorge

    Leiria, Portugal

  • Santa Casa da Misericórdia de Caminha

    Viana do Castelo, Portugal

  • Santa Casa da Misericórdia de Campo Maior

    Portalegre, Portugal

  • Santa Casa da Misericórdia de Espinho

    Aveiro, Portugal

  • Santa Casa da Misericórdia de Ferreira do Alentejo

    Beja, Portugal

  • Santa Casa da Misericórdia de Figueira de Castelo Rodrigo

    Guarda, Portugal

  • Santa Casa da Misericórdia de Gaia - ERPI José Tavares Bastos

    Porto, Portugal

  • Santa Casa da Misericórdia de Lisboa - Espaço ComVida

    Lisbon, Portugal

  • Santa Casa da Misericórdia de Mirandela

    Bragança, Portugal

  • Santa Casa da Misericórdia de Montemor-o-Novo

    Evora, Portugal

  • Santa Casa da Misericórdia de Ovar

    Aveiro, Portugal

  • Santa Casa da Misericórdia de Ponte de Lima

    Viana do Castelo, Portugal

  • Santa Casa da Misericórdia de Vila Real de Santo António

    Faro, Portugal

  • Santa Casa da Misericórdia de Vila Velha de Rodão

    Castelo Branco, Portugal

  • Santa Casa da Misericórdia de Vila do Porto

    Açores, Portugal

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