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New filling material that fights cavities could change how Kids' teeth are repaired

NCT ID NCT07703176

Disease control Sponsor: Minia University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 14, 2026 · Last updated Jul 16, 2026 · Updated 2 times

Summary

This study tests a newer filling material called Cention-N against standard composite resin for repairing cavities in children's first permanent molars. Cention-N releases minerals that may help prevent further decay. One hundred children aged 8-10 with similar cavities on both sides of the mouth will receive each material in a different molar, and the fillings will be compared over 12 months for appearance, fit, and how well they hold up, along with the children's quality of life.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Cention-N, a tooth-colored restorative material that releases fluoride, calcium, and hydroxide ions to help remineralize teeth
What this could lead to
If successful, Cention-N could offer a more durable, cavity-fighting alternative to standard fillings for children's first permanent molars.
What could go wrong
This is a small, early-stage trial with only 100 children over 12 months. Results may not apply to other teeth or ages, and long-term benefits are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2026

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

8 to 10 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Clinical: 1. Children aged 8-10 years. 2. Children classified as ASA physical status I or II. 3. Children demonstrate positive or definitely positive behavior (scores 3 or 4 on the Frankl Behavior Rating Scale). 4. Children who are available for regular recall visits throughout the study period. 5. Presence of bilateral carious lesions in permanent first molars, with a clear description of lesion depth whenever possible. 6. Asymptomatic vital permanent first molars showing no clinical or radiographic signs of pathology. Radiographic: 1. Normal lamina dura and periodontal ligament space. 2. No apical radiolucency. Exclusion Criteria: Clinical: 1. Children with behavioral difficulties or without signed parental consent. 2. Children are classified as ASA physical status class III or higher. 3. Teeth presenting clinical signs of pulpitis or necrosis (e.g., nocturnal pain, fistula, abscess, pulp exposure, or pathological mobility). Radiographic: 1. Evidence of abnormal radiolucency involving the pulp chamber or root apex. 2. Detection of furcal bone radiolucency or abnormal root resorption.

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Conditions

The condition(s) this trial relates to.

dental caries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dental caries Dental caries in young permanent teeth

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Faculty of Dentistry, Minya university

    RECRUITING

    Minya, Asyut Governorate, Egypt

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