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New gel could boost bone healing for dental implants

NCT ID NCT07099846

Disease control Sponsor: University of Parma Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tests whether a gel made from hyaluronic acid and polynucleotides, mixed with a bone graft, helps preserve bone after a tooth extraction. 40 adults needing a single tooth pulled will either get the gel treatment or let the socket heal naturally. After 4 months, a dental implant is placed using a digital workflow, and bone changes are measured with 3D X-rays.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
bovine-derived bone graft mixed with hyaluronic acid and polynucleotide gel
What this could lead to
If it works, this could improve bone healing after tooth extraction and make dental implants more successful.
What could go wrong
This is a small early-stage trial with only 40 people, so results may not apply to everyone. The gel might not improve bone preservation compared to natural healing.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2025

Expected to finish

May 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

25 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ≥25-year-old males and females; * good systemic health (self-assessment); * presence of an unrestorable/hopeless tooth with periodontal attachment and buccal bone preserved at least for 2/3rd of the root and not associated with acute periapical pathology; * full mouth bleeding and plaque scores ≤ 25% Exclusion Criteria: * uncontrolled or untreated periodontal disease; * history of local (head and neck) radiation therapy in the past 5 years; * acute endodontic lesion in the test tooth or in the neighbouring areas to the extraction procedure (sites with presence of an asymptomatic chronic lesion are eligible); * medical history that includes uncontrolled diabetes or hepatic or renal disease, or other serious medical conditions that can impact on bone metabolism (e.g. rheumatoid arthritis, osteoporosis) or transmittable diseases (e.g. HIV-related disease); * history of alcohol or drug abuse; * smokers of ≥10 cigarettes a day; * self-reported pregnancy or lactation.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cad/cam Hyaluronic acid Implant-supported single crowns Socket preservation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Centro di Odontoiatria

    RECRUITING

    Parma, 43126, Italy

  • Centro di Odontoiatria, Dipartimento di Medicina e Chirurgia, Università di Parma

    RECRUITING

    Parma, 43126, Italy

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