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Can a natural compound help preserve jawbone after tooth loss?

NCT ID NCT07765745

Disease control Sponsor: Kafrelsheikh University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 14, 2026 · Last updated Aug 14, 2026

Summary

This trial tests whether a gel made from thymoquinone, a compound found in black seed oil, can help preserve bone density and width in the jaw after a tooth is removed. Adults aged 18 to 50 who need an upper back tooth extracted may participate. Participants will receive either a standard gel foam, a thymoquinone gel, or a nano-formulated thymoquinone gel placed in the socket, and bone changes will be tracked with 3D imaging.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
0.2% thymoquinone gel (including a nano-formulated version), applied to the tooth socket after extraction
What this could lead to
If it works, this could point toward a simple, natural way to preserve jawbone shape and density after tooth removal, potentially improving healing and future dental implant success.
What could go wrong
This is a small, early-stage trial, so results may not be conclusive or widely applicable. The gel is experimental and its effectiveness and safety are not yet established.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age: 18-50 years. * Both sexes. * Patients requiring extraction of upper posterior teeth will be recruited. Exclusion Criteria: * Healthy subjects with intact sockets after extraction. * Normal mouth opening and good oral hygiene. * No systemic conditions affecting bone healing.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bone density Bone width Radiographic evaluation Socket preservation Thymoquinone Tooth extraction

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Kafrelsheikh University

    RECRUITING

    Kafr ash Shaykh, Kafrelsheikh, 33516, Egypt

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