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Aloe vera powder tested as a natural way to save jawbone after tooth loss

NCT ID NCT07736053

Disease control Sponsor: Cairo University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This trial tests whether acemannan aloe vera powder, placed into the socket right after a tooth is pulled, can better preserve the jawbone compared to letting the socket heal on its own. Healthy adults needing a front tooth extraction will be randomly assigned to receive the aloe vera treatment or natural healing. Researchers will use CT scans and bone samples taken months later to measure bone width and new bone formation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
acemannan aloe vera powder extract applied into the tooth socket after extraction
What this could lead to
If effective, this could offer a simple, natural way to preserve jawbone after tooth removal, potentially improving outcomes for future dental implants.
What could go wrong
This is a small, early-stage trial with only 26 participants, so results may not apply broadly. The aloe vera extract may not improve bone healing over natural recovery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

26 people

The number who actually took part.

Started

Oct 2024

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Non-restorable tooth in maxillary or mandibular anterior esthetic region. * Intact or minimally affected buccal plate of bone. * Patients at least 18 years or older. * Motivated patients, agree to sign the written informed consent and complete the follow-up period. Exclusion Criteria: * Infection at the extraction site. * Smokers more than 10 cigarettes per day . * Patients undergoing or having a history of radiotherapy, chemotherapy, or bisphosphonate therapy . * Systemic conditions that may compromise healing or bone metabolism (e.g., uncontrolled diabetes, hyperthyroidism) . * Patients on medication that may interfere with healing (Corticosteroids, Bisphosphonate, Chemo/radio therapy) * Systemic diseases or medications that affect blood clotting * Pregnant females or those planning to get pregnant during the study period (American Dental Association, 2011).

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Socket preservation

Contacts and locations

Locations

  • Egypt Faculty of Dentistry Cairo University

    Cairo, Egypt, 12613, Egypt

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