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Tooth-Derived graft material tested for better jawbone preservation

NCT ID NCT06318650

Disease control Sponsor: Cairo University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 01, 2026 · Last updated Jul 02, 2026 · Updated 1 time

Summary

This trial tests whether a graft made from donated teeth (allogeneic dentin matrix) can preserve the jawbone's shape and volume after a tooth extraction as well as or better than a standard bone graft. Adults aged 20–55 with a single-rooted tooth that cannot be saved and has healthy surrounding bone may join. Participants receive either the dentin graft or the bone graft immediately after extraction, and the changes in bone width and height are measured over six months using clinical exams and 3D X-rays.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
allogeneic dentin matrix
What this could lead to
If effective, this approach could offer a new, natural material for preserving jawbone shape and volume after tooth removal, potentially improving dental implant outcomes.
What could go wrong
This is a small, early-stage trial with only 22 participants. The dentin matrix may not perform better than the standard bone graft, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

22 people

The number who actually took part.

Started

Feb 2024

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 55 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients between the age of 20-55. * Single rooted, non-restorable or hopeless tooth with adjacent teeth. * Extraction socket with no more than 50% buccal bone loss * Patients accept 6-months follow-up period (cooperative patients). * Patients provide an informed consent. Exclusion Criteria: * Patients with uncontrolled systemic disease. * Patient with severe para-functional habits. * Patients with poor maintenance of oral hygiene. * Pregnancy. * Smokers. * Patients taking any medications that could compromise healing.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Socket preservation

Contacts and locations

Locations

  • Faculty of Dentistry Cairo University

    Cairo, 12613, Egypt

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