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Wisdom tooth transplant showdown: which nerve strategy wins?

NCT ID NCT07291531

Disease control Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares three ways to handle the dental pulp (tooth nerve) after transplanting a wisdom tooth to replace a damaged molar. 360 people aged 18-40 will be randomly assigned to receive either standard root canal treatment weeks after surgery, a special root tip procedure during surgery plus later root canal, or just trimming the root tip to try to keep the nerve alive. The goal is to see which approach leads to the best long-term tooth survival and health over 5 years.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
root canal therapy or apical surgery
What this could lead to
If successful, this could establish the best way to manage the tooth nerve after a wisdom tooth transplant, improving long-term tooth survival and function.
What could go wrong
This is an early-stage trial with no results yet, and the best strategy may not be clearly better than others. Risks include infection, root resorption, or tooth loss.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 360 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jan 2026

An estimate. Start dates often move.

Expected to finish

Jun 2032

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Aged 18-40 years. 2. Requires extraction of a non-restorable first or second molar AND possesses a fully developed, morphologically healthy ipsilateral third molar as a donor tooth. 3. Willing and able to provide written informed consent. Exclusion Criteria: 1. Presence of acute infection or insufficient bone volume at the recipient site. 2. Donor tooth exhibits caries, periapical pathology, or periodontal disease. 3. Uncontrolled systemic disease (e.g., diabetes, immunosuppression), pregnancy, or lactation. Smoking habit of \>10 cigarettes per day. 4. Inability or unwillingness to comply with the long-term follow-up schedule.

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Conditions

The condition(s) this trial relates to.

dental pulp disorder impacted teeth, multiple Tooth Avulsion Tooth, Impacted

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dental pulp diseases Tooth avulsion Tooth, impacted

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • The Second Affiliated Hospital of Zhejiang University School of Medicine

    Hangzhou, Zhejiang, 310002, China

More trials for these conditions

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