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Melanoma drug combo trial halted early – only 5 patients enrolled

NCT ID NCT04527549

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 4 times

Summary

This study tested whether adding hydroxychloroquine (a malaria drug) to standard targeted therapy (dabrafenib and trametinib) could help control advanced melanoma that had spread or could not be removed by surgery. It was designed for people with a specific gene mutation (BRAF V600E/K) and high LDH levels in their blood. The trial was stopped early after enrolling only 5 participants, so the results are limited.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

5 people

The number who actually took part.

Started

Jun 2021

Finished

Jan 2024

Lead sponsor

A research network

The lead sponsor is a research network or cooperative group.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient must have locally advanced unresectable stage IIIC or stage IV melanoma * Patient must have BRAF V600E or BRAF V600K tumor genotype based on a Clinical Laboratory Improvement Act (CLIA) approved assay * Patient must have serum LDH \> Upper limit of normal per institution standards * Patient must have measurable disease by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1. Baseline measurements of sites of disease must be obtained within 3 weeks prior to study randomization * Patient must have been treated with prior immune checkpoint inhibitor therapy (anti PD-1 antibody, anti-CTLA-4 antibody or a combination regimen including either or both agents) either in the adjuvant or metastatic setting. Patient may have received investigational agents in combination with standard therapy, as long as it was adhering to the timeframes below * Patient must have discontinued active immunotherapy (IL-2, interferon, anti-CTLA-4 antibody, anti-PD-1 antibody etc.) or chemotherapy at least 4 weeks prior to randomization * Patient must have discontinued any oral targeted therapy at least 2 weeks prior to randomization * Patient may have been treated with prior adjuvant therapy including combined BRAF and MEK inhibitor therapy. Patients will be eligible if they tolerated this therapy and did not discontinue the therapy due to toxicity AND \>= 6 months have elapsed since the end of adjuvant BRAF and MEK inhibition. * Patient may have been treated with prior chemotherapy or radiation therapy * Patient must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 * Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial * All females of childbearing potential must have a blood test or urine study within 14 days prior to randomization to rule out pregnancy. * Women of childbearing potential and sexually active males must not expect to conceive or father children by using accepted and effective method(s) of contraception or abstaining from sexual intercourse for the duration of their participation in the study and for 4 months after the last dose of protocol treatment * Patient must have recovered from clinically significant reversible toxicities from previous treatment prior to randomization. Abnormal laboratory values may be grade 1, as long as they meet the eligibility criteria for organ and marrow function * Patient must be able to swallow and retain oral medication and must not have any clinically significant gastrointestinal abnormalities that may alter absorption such as malabsorption syndrome or major resection of the stomach or bowels * Patient must have the ability to understand and the willingness to sign a written informed consent document. Patients with impaired decision-making capacity (IDMC) who have a legally authorized representative (LAR) or caregiver and/or family member available will also be considered eligible * Absolute neutrophil count \>= 1,500/mcL (obtained =\< 14 days prior to protocol randomization) * Platelets \>= 100,000/mcL (obtained =\< 14 days prior to protocol randomization) * Total bilirubin =\< institutional upper limit of normal (ULN) (obtained =\< 14 days prior to protocol randomization) * Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase \[SGOT\])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase \[SGPT\]) =\< 3.0 x institutional ULN (obtained =\< 14 days prior to protocol randomization) * Creatinine =\< 1.5 x institutional ULN (obtained =\< 14 days prior to protocol randomization) * Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial * For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated * Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load * Patient with asymptomatic new or progressive brain metastases (active brain metastases) are eligible if the treating physician determines that CNS specific treatment is not required * NOTE: Patient with treated brain metastases are eligible. No brain imaging is required, however, 1 week must elapse after gamma knife therapy. Patient treated with whole brain radiation that have been stable for 2 months are eligible. Patient are excluded if they have leptomeningeal disease or metastases causing spinal cord compression that are symptomatic or untreated or not stable (documented by imaging) for at least 3 months or requiring corticosteroids. Patients on a stable dose of corticosteroids for at least 1 month or who have been off of corticosteroids for at least 1 week are eligible Exclusion Criteria: * Receiving any other investigational anticancer therapy during the period on study or the 4 weeks prior to randomization * Patients received BRAF and MEK inhibitor therapy in the metastatic setting * Patients who are experiencing an objective partial response to immunotherapy at the time of study enrollment * Pregnant or breast-feeding; due to the potential harm to an unborn fetus and possible risk for adverse events in nursing infants with the treatment regimens being used. A female of childbearing potential is defined as any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy; or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months) * A history of interstitial lung disease (ILD) or chronic pneumonitis * NOTE: If there is radiographic evidence of ILD that is clinically insignificant and asymptomatic, the patient would be eligible * Porphyria or psoriasis due to risk of disease exacerbation unless the disease is well controlled and they are under the care of a specialist for the disorder who agrees to monitor the patient for exacerbations * Previously documented retinal vein occlusion * A history or evidence of increased cardiovascular risk including: * Left ventricular ejection fraction (LVEF) \< institutional lower limit of normal measured within 14 days prior to randomization * A QT interval corrected for heart rate using the Bazett's formula \>= 480 msec * Current clinically significant uncontrolled arrhythmias. Exception: Patients with controlled atrial fibrillation for \> 30 days prior to randomization are eligible * Acute coronary syndromes (including myocardial infarction and unstable angina), coronary angioplasty, or stenting within 6 months prior to randomization * Abnormal cardiac valve morphology (\>= grade 2) documented by echocardiogram unless a cardiologist concludes the valve abnormality is not clinically significant. Patients with grade 1 abnormalities (i.e., mild regurgitation/stenosis) are eligible * Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class 2B or better * Serious concurrent infection or medical illness, including psychiatric disorders, which would jeopardize the ability of the patient to receive the treatment outlined in this protocol with reasonable safety * Receiving concurrent therapy for their tumor (i.e. chemotherapeutics or investigational agents). Radiotherapy delivered to palliate pain is allowed as long as it is not targeting a lesion that meets RECIST criteria for progression. Radiation therapy to the surgical bed with gamma knife radiotherapy while on treatment during the first cycle is allowed for small volume surgically resected brain metastases. Gamma knife radiotherapy for known active, asymptomatic small volume central nervous system (CNS) lesions may be performed during the first cycle while on study. Radiotherapy for new CNS lesions identified beyond the first cycle is not allowed on study * Immediate or delayed hypersensitivity reaction or idiosyncrasy to drugs chemically related to study drug, or excipients or to dimethyl sulfoxide (DMSO) * Prior cytochrome P450 enzyme -inducing anticonvulsant drugs (extended-interval aminoglycoside dosing \[EIADs\]) (i.e. phenytoin, carbamazepine, phenobarbital, primidone or oxcarbazepine) within 4 weeks prior to randomization * Current use of a prohibited medication described in the protocol due to potential drug-drug interaction

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Alaska Breast Care and Surgery LLC

    Anchorage, Alaska, 99508, United States

  • Alaska Oncology and Hematology LLC

    Anchorage, Alaska, 99508, United States

  • Alaska Women's Cancer Care

    Anchorage, Alaska, 99508, United States

  • Alegent Health Bergan Mercy Medical Center

    Omaha, Nebraska, 68124, United States

  • Alegent Health Immanuel Medical Center

    Omaha, Nebraska, 68122, United States

  • Alegent Health Lakeside Hospital

    Omaha, Nebraska, 68130, United States

  • Alegent Health Mercy Hospital

    Council Bluffs, Iowa, 51503, United States

  • Anchorage Associates in Radiation Medicine

    Anchorage, Alaska, 98508, United States

  • Anchorage Oncology Centre

    Anchorage, Alaska, 99508, United States

  • Anchorage Radiation Therapy Center

    Anchorage, Alaska, 99504, United States

  • Armes Family Cancer Center

    Findlay, Ohio, 45840, United States

  • Atrium Medical Center-Middletown Regional Hospital

    Franklin, Ohio, 45005-1066, United States

  • Bay Area Hospital

    Coos Bay, Oregon, 97420, United States

  • Beebe Health Campus

    Rehoboth Beach, Delaware, 19971, United States

  • Beebe Medical Center

    Lewes, Delaware, 19958, United States

  • Beebe South Coastal Health Campus

    Frankford, Delaware, 19945, United States

  • Bethesda North Hospital

    Cincinnati, Ohio, 45242, United States

  • Blanchard Valley Hospital

    Findlay, Ohio, 45840, United States

  • Broadlawns Medical Center

    Des Moines, Iowa, 50314, United States

  • CHI Health Good Samaritan

    Kearney, Nebraska, 68847, United States

  • CHI Health Saint Francis

    Grand Island, Nebraska, 68803, United States

  • CHI Saint Vincent Cancer Center Hot Springs

    Hot Springs, Arkansas, 71913, United States

  • Cancer Center at Saint Joseph's

    Phoenix, Arizona, 85004, United States

  • Carle Cancer Center

    Urbana, Illinois, 61801, United States

  • Carle Physician Group-Effingham

    Effingham, Illinois, 62401, United States

  • Carle Physician Group-Mattoon/Charleston

    Mattoon, Illinois, 61938, United States

  • Carle on Vermilion

    Danville, Illinois, 61832, United States

  • Cedars Sinai Medical Center

    Los Angeles, California, 90048, United States

  • Central Care Cancer Center - Bolivar

    Bolivar, Missouri, 65613, United States

  • Central Care Cancer Center - Garden City

    Garden City, Kansas, 67846, United States

  • Central Care Cancer Center - Great Bend

    Great Bend, Kansas, 67530, United States

  • Christiana Care Health System-Christiana Hospital

    Newark, Delaware, 19718, United States

  • Christiana Care Health System-Concord Health Center

    Chadds Ford, Pennsylvania, 19317, United States

  • Christiana Care Health System-Wilmington Hospital

    Wilmington, Delaware, 19801, United States

  • Clackamas Radiation Oncology Center

    Clackamas, Oregon, 97015, United States

  • Commonwealth Cancer Center-Corbin

    Corbin, Kentucky, 40701, United States

  • Cox Cancer Center Branson

    Branson, Missouri, 65616, United States

  • CoxHealth South Hospital

    Springfield, Missouri, 65807, United States

  • Creighton University Medical Center

    Omaha, Nebraska, 68131, United States

  • Dayton Physician LLC-Miami Valley Hospital North

    Dayton, Ohio, 45415, United States

  • Dayton Physicians LLC-Atrium

    Franklin, Ohio, 45005, United States

  • Dayton Physicians LLC-Miami Valley South

    Centerville, Ohio, 45459, United States

  • Dayton Physicians LLC-Upper Valley

    Troy, Ohio, 45373, United States

  • Dayton Physicians LLC-Wayne

    Greenville, Ohio, 45331, United States

  • Delaware Clinical and Laboratory Physicians PA

    Newark, Delaware, 19713, United States

  • Delbert Day Cancer Institute at PCRMC

    Rolla, Missouri, 65401, United States

  • Flaget Memorial Hospital

    Bardstown, Kentucky, 40004, United States

  • Franciscan Research Center-Northwest Medical Plaza

    Tacoma, Washington, 98405, United States

  • Freeman Health System

    Joplin, Missouri, 64804, United States

  • Good Samaritan Hospital - Cincinnati

    Cincinnati, Ohio, 45220, United States

  • Good Samaritan Regional Health Center

    Mount Vernon, Illinois, 62864, United States

  • Greater Dayton Cancer Center

    Kettering, Ohio, 45409, United States

  • Greater Regional Medical Center

    Creston, Iowa, 50801, United States

  • Harrison HealthPartners Hematology and Oncology-Bremerton

    Bremerton, Washington, 98310, United States

  • Harrison HealthPartners Hematology and Oncology-Poulsbo

    Poulsbo, Washington, 98370, United States

  • Harrison Medical Center

    Bremerton, Washington, 98310, United States

  • Heartland Regional Medical Center

    Saint Joseph, Missouri, 64506, United States

  • Helen F Graham Cancer Center

    Newark, Delaware, 19713, United States

  • Highline Medical Center-Main Campus

    Burien, Washington, 98166, United States

  • Huntsman Cancer Institute/University of Utah

    Salt Lake City, Utah, 84112, United States

  • Indu and Raj Soin Medical Center

    Beavercreek, Ohio, 45431, United States

  • Iowa Lutheran Hospital

    Des Moines, Iowa, 50316, United States

  • Iowa Methodist Medical Center

    Des Moines, Iowa, 50309, United States

  • Jewish Hospital

    Louisville, Kentucky, 40202, United States

  • Jewish Hospital Medical Center South

    Shepherdsville, Kentucky, 40165, United States

  • Kadlec Clinic Hematology and Oncology

    Kennewick, Washington, 99336, United States

  • Katmai Oncology Group

    Anchorage, Alaska, 99508, United States

  • Kettering Medical Center

    Kettering, Ohio, 45429, United States

  • Laura and Isaac Perlmutter Cancer Center at NYU Langone

    New York, New York, 10016, United States

  • Littleton Adventist Hospital

    Littleton, Colorado, 80122, United States

  • Longmont United Hospital

    Longmont, Colorado, 80501, United States

  • Loyola Center for Health at Burr Ridge

    Burr Ridge, Illinois, 60527, United States

  • Loyola Medicine Homer Glen

    Homer Glen, Illinois, 60491, United States

  • Loyola University Medical Center

    Maywood, Illinois, 60153, United States

  • Marjorie Weinberg Cancer Center at Loyola-Gottlieb

    Melrose Park, Illinois, 60160, United States

  • Marshfield Clinic - Ladysmith Center

    Ladysmith, Wisconsin, 54848, United States

  • Marshfield Clinic - Wisconsin Rapids Center

    Wisconsin Rapids, Wisconsin, 54494, United States

  • Marshfield Clinic-Chippewa Center

    Chippewa Falls, Wisconsin, 54729, United States

  • Marshfield Clinic-Minocqua Center

    Minocqua, Wisconsin, 54548, United States

  • Marshfield Clinic-Wausau Center

    Wausau, Wisconsin, 54401, United States

  • Marshfield Medical Center - Weston

    Weston, Wisconsin, 54476, United States

  • Marshfield Medical Center-EC Cancer Center

    Eau Claire, Wisconsin, 54701, United States

  • Marshfield Medical Center-Marshfield

    Marshfield, Wisconsin, 54449, United States

  • Marshfield Medical Center-Rice Lake

    Rice Lake, Wisconsin, 54868, United States

  • Marshfield Medical Center-River Region at Stevens Point

    Stevens Point, Wisconsin, 54482, United States

  • Mary Greeley Medical Center

    Ames, Iowa, 50010, United States

  • Mayo Clinic Hospital in Arizona

    Phoenix, Arizona, 85054, United States

  • Mayo Clinic in Arizona

    Scottsdale, Arizona, 85259, United States

  • Mayo Clinic in Rochester

    Rochester, Minnesota, 55905, United States

  • McFarland Clinic PC - Ames

    Ames, Iowa, 50010, United States

  • McFarland Clinic PC-Boone

    Boone, Iowa, 50036, United States

  • McFarland Clinic PC-Jefferson

    Jefferson, Iowa, 50129, United States

  • McFarland Clinic PC-Marshalltown

    Marshalltown, Iowa, 50158, United States

  • McFarland Clinic PC-Trinity Cancer Center

    Fort Dodge, Iowa, 50501, United States

  • MedStar Franklin Square Medical Center/Weinberg Cancer Institute

    Baltimore, Maryland, 21237, United States

  • MedStar Georgetown University Hospital

    Washington D.C., District of Columbia, 20007, United States

  • Medical Oncology Hematology Consultants PA

    Newark, Delaware, 19713, United States

  • Medical Oncology and Hematology Associates-Des Moines

    Des Moines, Iowa, 50309, United States

  • Medical Oncology and Hematology Associates-West Des Moines

    Clive, Iowa, 50325, United States

  • Mercy Cancer Center-West Lakes

    Clive, Iowa, 50325, United States

  • Mercy Clinic-Rolla-Cancer and Hematology

    Rolla, Missouri, 65401, United States

  • Mercy Hospital Fort Smith

    Fort Smith, Arkansas, 72903, United States

  • Mercy Hospital Joplin

    Joplin, Missouri, 64804, United States

  • Mercy Hospital Oklahoma City

    Oklahoma City, Oklahoma, 73120, United States

  • Mercy Hospital Saint Louis

    St Louis, Missouri, 63141, United States

  • Mercy Hospital South

    St Louis, Missouri, 63128, United States

  • Mercy Hospital Springfield

    Springfield, Missouri, 65804, United States

  • Mercy Hospital Washington

    Washington, Missouri, 63090, United States

  • Mercy Medical Center

    Durango, Colorado, 81301, United States

  • Mercy Medical Center - Des Moines

    Des Moines, Iowa, 50314, United States

  • Mercy Medical Center-West Lakes

    West Des Moines, Iowa, 50266, United States

  • Methodist West Hospital

    West Des Moines, Iowa, 50266-7700, United States

  • Miami Valley Hospital

    Dayton, Ohio, 45409, United States

  • Miami Valley Hospital North

    Dayton, Ohio, 45415, United States

  • Miami Valley Hospital South

    Centerville, Ohio, 45459, United States

  • Midlands Community Hospital

    Papillion, Nebraska, 68046, United States

  • Mission Cancer and Blood - Laurel

    Des Moines, Iowa, 50314, United States

  • Mission Hope Medical Oncology - Arroyo Grande

    Arroyo Grande, California, 93420, United States

  • Mission Hope Medical Oncology - Santa Maria

    Santa Maria, California, 93444, United States

  • Oncology Hematology Care Inc-Kenwood

    Cincinnati, Ohio, 45236, United States

  • Orion Cancer Care

    Findlay, Ohio, 45840, United States

  • Pacific Central Coast Health Center-San Luis Obispo

    San Luis Obispo, California, 93401, United States

  • Pacific Gynecology Specialists

    Seattle, Washington, 98104, United States

  • Parker Adventist Hospital

    Parker, Colorado, 80138, United States

  • PeaceHealth Saint John Medical Center

    Longview, Washington, 98632, United States

  • PeaceHealth Saint Joseph Medical Center

    Bellingham, Washington, 98225, United States

  • PeaceHealth Southwest Medical Center

    Vancouver, Washington, 98664, United States

  • PeaceHealth United General Medical Center

    Sedro-Woolley, Washington, 98284, United States

  • Penrose-Saint Francis Healthcare

    Colorado Springs, Colorado, 80907, United States

  • Porter Adventist Hospital

    Denver, Colorado, 80210, United States

  • Providence Alaska Medical Center

    Anchorage, Alaska, 99508, United States

  • Providence Cancer Institute Clackamas Clinic

    Clackamas, Oregon, 97015, United States

  • Providence Newberg Medical Center

    Newberg, Oregon, 97132, United States

  • Providence Portland Medical Center

    Portland, Oregon, 97213, United States

  • Providence Regional Cancer Partnership

    Everett, Washington, 98201, United States

  • Providence Regional Cancer System-Aberdeen

    Aberdeen, Washington, 98520, United States

  • Providence Regional Cancer System-Centralia

    Centralia, Washington, 98531, United States

  • Providence Regional Cancer System-Lacey

    Lacey, Washington, 98503, United States

  • Providence Regional Cancer System-Shelton

    Shelton, Washington, 98584, United States

  • Providence Regional Cancer System-Yelm

    Yelm, Washington, 98597, United States

  • Providence Saint Joseph Medical Center/Disney Family Cancer Center

    Burbank, California, 91505, United States

  • Providence Saint Mary Regional Cancer Center

    Walla Walla, Washington, 99362, United States

  • Providence Saint Vincent Medical Center

    Portland, Oregon, 97225, United States

  • Reid Health

    Richmond, Indiana, 47374, United States

  • Rocky Mountain Cancer Centers-Longmont

    Longmont, Colorado, 80501, United States

  • Rocky Mountain Cancer Centers-Penrose

    Colorado Springs, Colorado, 80907, United States

  • Rush - Copley Medical Center

    Aurora, Illinois, 60504, United States

  • Rush-Copley Healthcare Center

    Yorkville, Illinois, 60560, United States

  • Saint Anthony Hospital

    Lakewood, Colorado, 80228, United States

  • Saint Anthony Regional Hospital

    Carroll, Iowa, 51401, United States

  • Saint Anthony's Health

    Alton, Illinois, 62002, United States

  • Saint Charles Health System

    Bend, Oregon, 97701, United States

  • Saint Charles Health System-Redmond

    Redmond, Oregon, 97756, United States

  • Saint Clare Hospital

    Lakewood, Washington, 98499, United States

  • Saint Elizabeth Boardman Hospital

    Boardman, Ohio, 44512, United States

  • Saint Elizabeth Hospital

    Enumclaw, Washington, 98022, United States

  • Saint Elizabeth Regional Medical Center

    Lincoln, Nebraska, 68510, United States

  • Saint Elizabeth Youngstown Hospital

    Youngstown, Ohio, 44501, United States

  • Saint Francis Cancer Center

    Colorado Springs, Colorado, 80923, United States

  • Saint Francis Hospital

    Federal Way, Washington, 98003, United States

  • Saint Joseph Hospital East

    Lexington, Kentucky, 40509, United States

  • Saint Joseph London

    London, Kentucky, 40741, United States

  • Saint Joseph Radiation Oncology Resource Center

    Lexington, Kentucky, 40504, United States

  • Saint Joseph Regional Cancer Center

    Bryan, Texas, 77802, United States

  • Saint Joseph Warren Hospital

    Warren, Ohio, 44484, United States

  • Saint Louis Cancer and Breast Institute-Ballwin

    Ballwin, Missouri, 63011, United States

  • Saint Louis Cancer and Breast Institute-South City

    St Louis, Missouri, 63109, United States

  • Saint Luke's Cancer Institute - Boise

    Boise, Idaho, 83712, United States

  • Saint Luke's Cancer Institute - Fruitland

    Fruitland, Idaho, 83619, United States

  • Saint Luke's Cancer Institute - Meridian

    Meridian, Idaho, 83642, United States

  • Saint Luke's Cancer Institute - Nampa

    Nampa, Idaho, 83686, United States

  • Saint Luke's Cancer Institute - Twin Falls

    Twin Falls, Idaho, 83301, United States

  • Saint Mary Corwin Medical Center

    Pueblo, Colorado, 81004, United States

  • Saint Patrick Hospital - Community Hospital

    Missoula, Montana, 59802, United States

  • Saints Mary and Elizabeth Hospital

    Louisville, Kentucky, 40215, United States

  • Southwest Oncology PC

    Durango, Colorado, 81301, United States

  • Springfield Regional Cancer Center

    Springfield, Ohio, 45504, United States

  • Springfield Regional Medical Center

    Springfield, Ohio, 45505, United States

  • Swedish Cancer Institute-Edmonds

    Edmonds, Washington, 98026, United States

  • Swedish Cancer Institute-Issaquah

    Issaquah, Washington, 98029, United States

  • Swedish Medical Center-Ballard Campus

    Seattle, Washington, 98107, United States

  • Swedish Medical Center-Cherry Hill

    Seattle, Washington, 98122-5711, United States

  • Swedish Medical Center-First Hill

    Seattle, Washington, 98122, United States

  • The Carle Foundation Hospital

    Urbana, Illinois, 61801, United States

  • TidalHealth Nanticoke / Allen Cancer Center

    Seaford, Delaware, 19973, United States

  • TriHealth Cancer Institute-Anderson

    Cincinnati, Ohio, 45255, United States

  • TriHealth Cancer Institute-Westside

    Cincinnati, Ohio, 45247, United States

  • Trinity Regional Medical Center

    Fort Dodge, Iowa, 50501, United States

  • UM Sylvester Comprehensive Cancer Center at Aventura

    Aventura, Florida, 33180, United States

  • UM Sylvester Comprehensive Cancer Center at Coral Gables

    Coral Gables, Florida, 33146, United States

  • UM Sylvester Comprehensive Cancer Center at Deerfield Beach

    Deerfield Beach, Florida, 33442, United States

  • UM Sylvester Comprehensive Cancer Center at Kendall

    Miami, Florida, 33176, United States

  • UM Sylvester Comprehensive Cancer Center at Plantation

    Plantation, Florida, 33324, United States

  • University of Miami Miller School of Medicine-Sylvester Cancer Center

    Miami, Florida, 33136, United States

  • University of Pennsylvania/Abramson Cancer Center

    Philadelphia, Pennsylvania, 19104, United States

  • University of Pittsburgh Cancer Institute (UPCI)

    Pittsburgh, Pennsylvania, 15232, United States

  • UofL Health Medical Center Northeast

    Louisville, Kentucky, 40245, United States

  • Upper Valley Medical Center

    Troy, Ohio, 45373, United States

  • Wayne Hospital

    Greenville, Ohio, 45331, United States

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Other studies related to the condition(s) this trial covers.