PATHOLOGIC STAGE IV CUTANEOUS MELANOMA AJCC V8
Clinical trials for PATHOLOGIC STAGE IV CUTANEOUS MELANOMA AJCC V8 explained in plain language.
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New drug combo trial hopes to tame advanced cancers
Disease control Recruiting nowThis early-phase study tests a new drug called IACS-6274, given alone or with other medicines, in people with advanced solid tumors (like melanoma, ovarian, or head and neck cancers). The main goal is to find the safest dose and understand side effects. About 54 adults will take …
Matched conditions: PATHOLOGIC STAGE IV CUTANEOUS MELANOMA AJCC V8
Phase: PHASE1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated May 26, 2026 02:28 UTC
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New drug combo targets melanoma brain tumors
Disease control Recruiting nowThis study tests two drugs, binimetinib and encorafenib, in people with advanced melanoma that has spread to the brain. The drugs block enzymes that help cancer cells grow. The goal is to see if this combination can control the disease and improve survival. About 35 adults with a…
Matched conditions: PATHOLOGIC STAGE IV CUTANEOUS MELANOMA AJCC V8
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated May 22, 2026 13:53 UTC
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New combo aims to shrink brain tumors in advanced melanoma
Disease control Recruiting nowThis study tests whether a combination of targeted drugs (encorafenib and binimetinib) plus an immunotherapy (nivolumab) works better than two immunotherapies (ipilimumab and nivolumab) for people with BRAF-V600 mutant melanoma that has spread to the brain. About 112 adults with …
Matched conditions: PATHOLOGIC STAGE IV CUTANEOUS MELANOMA AJCC V8
Phase: PHASE2 • Sponsor: SWOG Cancer Research Network • Aim: Disease control
Last updated May 19, 2026 12:01 UTC
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Engineered immune cells take on Hard-to-Treat cancers in early trial
Disease control Recruiting nowThis early-phase trial tests a new treatment for people with advanced melanoma or other solid tumors that have spread. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack cancer cells. The goal is to find a safe dose and see if t…
Matched conditions: PATHOLOGIC STAGE IV CUTANEOUS MELANOMA AJCC V8
Phase: PHASE1 • Sponsor: Anusha Kalbasi • Aim: Disease control
Last updated May 18, 2026 12:13 UTC
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Donor immune cells take on brain melanoma in new trial
Disease control Recruiting nowThis study tests a new treatment for advanced melanoma that has spread to the brain. It combines chemotherapy (temozolomide) with specially grown immune cells from a healthy donor (called NK cells). The goal is to see if this combination is safe and can shrink brain tumors. About…
Matched conditions: PATHOLOGIC STAGE IV CUTANEOUS MELANOMA AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: Kari Kendra • Aim: Disease control
Last updated May 14, 2026 12:02 UTC
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Gut bacteria may hold key to easing cancer treatment side effects
Knowledge-focused Recruiting nowThis study looks at how the bacteria in your gut might influence stomach issues like diarrhea and colitis caused by certain cancer drugs (immune checkpoint inhibitors). Researchers will collect stool, blood, and tissue samples from 800 people with melanoma, lung cancer, or genito…
Matched conditions: PATHOLOGIC STAGE IV CUTANEOUS MELANOMA AJCC V8
Phase: PHASE1 • Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated May 19, 2026 11:48 UTC