LOCALLY ADVANCED MELANOMA

This study tests a personalized vaccine made from a patient's own tumor proteins, combined with the immunotherapy drug pembrolizumab, for people with advanced solid tumors (like breast, lung, or skin cancer). The goal is to see if the combination is safe and helps the immune syst…

This study tests whether giving a lower, less frequent dose of the cancer drug atezolizumab can still control tumors while causing fewer side effects. About 30 adults with advanced lung, liver, skin, or sarcoma cancers will receive the drug alone or with other treatments. Researc…

This study tests a drug called avapritinib in people with advanced solid tumors that have spread and have specific gene changes (CKIT or PDGFRA mutations). The drug works by blocking enzymes that help cancer cells grow. The goal is to see if avapritinib can shrink or control thes…

This study tests whether a special nutritional drink called Oral Impact can reduce severe side effects from immunotherapy in 20 people with advanced melanoma that cannot be surgically removed. Participants take the drink starting one week before their standard immunotherapy treat…

This study looks at how immune cells called T cells change in people with advanced melanoma, lung cancer, or other solid tumors during anti-PD-1 treatment. Researchers will measure specific markers in blood samples to see if they can predict whether the therapy is working or if r…

This study looks at how the immune system responds to two different drug combinations in people with advanced melanoma that cannot be removed by surgery or has spread. Researchers will analyze immune cells from tumor samples and blood to compare the effects of the treatments. The…