Ecog-acrin Cancer Research Group

This study compares two treatments for people with stage III-IVA head and neck cancer who have already had surgery to remove their tumor. One group gets radiation therapy alone, and the other gets radiation plus the chemotherapy drug cisplatin. The goal is to see which approach b…

This study tests whether giving chemotherapy before standard surgery and radiation can help preserve the eye socket and skull base in people with advanced nasal and sinus cancer. About 82 participants will be randomly assigned to receive either chemo followed by surgery and radia…

This study tests whether adding daratumumab to standard lenalidomide and dexamethasone can delay or prevent smoldering myeloma from turning into active multiple myeloma. About 288 people with high-risk smoldering myeloma will participate. The goal is to see if the combination imp…

This study tests whether adding a special chemotherapy pump that delivers drugs directly to the liver (hepatic arterial infusion, or HAI) to standard chemotherapy helps people with colorectal cancer that has spread to the liver live longer. About 408 adults whose liver tumors can…

This study is for men whose prostate cancer has returned after surgery, shown by a rising PSA level. It tests whether adding a stronger drug combination (apalutamide plus abiraterone and prednisone) to standard radiation and hormone therapy can better control the cancer. For thos…

This study is for people with stomach cancer that has spread to the lining of the abdomen. It compares standard chemotherapy given through a vein to the same treatment plus an extra chemotherapy drug (paclitaxel) delivered directly into the belly through a small port. The goal is…

This study is for adults with a type of thyroid cancer that has stopped responding to standard treatment and has a specific gene change (BRAF V600E). It compares two drug approaches: cabozantinib alone versus a combination of dabrafenib and trametinib. The goal is to see which tr…

This study tests whether adding a fourth drug (bortezomib) to a standard three-drug combination (daratumumab, lenalidomide, and dexamethasone) works better for people newly diagnosed with multiple myeloma who are not eligible for early stem cell transplant. About 1,450 participan…

This study tests a system called CONCURxP that uses a special medication bag (WiseBag) and text message reminders to help people with metastatic breast cancer take their CDK4/6 inhibitor pills correctly. About 410 patients will either use the bag alone or the bag plus text remind…

This study tests a program called CostCOM that provides financial counseling and resources to cancer patients. The goal is to see if it helps them stick with their treatments and reduces the financial burden of medical costs. About 760 patients will take part.

This study looks at how social and genetic factors impact the long-term health of young adults who survived Hodgkin or non-Hodgkin lymphoma. Researchers will collect blood samples and health information from 2000 survivors to understand why some face more health problems after tr…

This study is for 100 adults with newly diagnosed glioblastoma. It tests if special MRI and PET scans can tell the difference between tumor growth and harmless changes caused by treatment. The goal is to improve how doctors read scans and make treatment decisions.

This study compares two ways of monitoring pancreatic cysts: more frequent check-ups versus less frequent ones. The goal is to see which approach leads to better outcomes for patients. About 4,600 people aged 50 to 75 with pancreatic cysts will take part. The study does not test …