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Could an extra dose of antibiotics during appendix surgery cut infection risk?

NCT ID NCT06860802

Disease control Sponsor: University of Michigan Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Aug 14, 2026 · Updated 3 times

Summary

This study looks at whether giving an extra dose of the antibiotic cefoxitin during appendix removal surgery can better prevent infections compared to the usual single dose before surgery. Researchers will measure antibiotic levels in blood, fat, and appendix tissue from 46 participants. The goal is to find the best dosing strategy to reduce infection, side effects, and antibiotic resistance.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
cefoxitin
What this could lead to
If successful, this could lead to better dosing guidelines for antibiotics during appendix surgery, reducing infections and side effects.
What could go wrong
This is a small, early-phase study with only 46 participants. The new dosing method may not prove better than the current standard, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

About 46 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2025

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of acute appendicitis and plan to undergo appendectomy at the University of Michigan Exclusion Criteria: * Prisoners * Patients that are pregnant * Patients with perforation or abscess on CT Scan

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Conditions

The condition(s) this trial relates to.

appendicitis disease Surgical Wound Infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Appendicitis (diagnosis)

Contacts and locations

Locations

  • Michigan Medicine

    Ann Arbor, Michigan, 48108, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.