University Of Southern California

This early-phase study tested a new drug called sEphB4-HSA combined with standard chemotherapy in 61 people with advanced or metastatic solid tumors (like head and neck, pancreatic, lung, and gallbladder cancers). The goal was to find the best dose and check for side effects. Res…

This study tests a combination of standard chemotherapy (bortezomib, dexamethasone), an immunotherapy (pembrolizumab), and a lab-modified virus (pelareorep) in people with multiple myeloma that has returned or stopped responding to treatment. The goal is to see if adding the viru…

This early-phase trial tests a new version of the chemotherapy drug paclitaxel, called FID-007, in 50 adults with advanced solid tumors that have stopped responding to standard treatments. The drug is wrapped in a special polymer to help it reach deeper into tumors while sparing …

This early-phase study tests whether a mix of immune-boosting drugs and targeted radiation can help the body fight advanced solid tumors that cannot be removed by surgery. About 14 adults with certain types of advanced skin cancer, sarcoma, or breast cancer will receive the treat…

This study looks at how well the drug enzalutamide works alone or with a radiation drug called radium-223 in men with advanced prostate cancer that has spread to bone. The goal is to see if the combination boosts the immune system and slows cancer growth. About 30 men will take p…

This study tests whether giving the immunotherapy drug cemiplimab before surgery can help shrink high-risk skin cancers that haven't spread far. About 35 adults with certain types of squamous cell skin cancer will receive the drug and then have surgery. The goal is to see if this…

This early-phase study tests two drugs together—guadecitabine and durvalumab—in people with advanced liver, pancreatic, bile duct, or gallbladder cancers that have spread. The goal is to find the safest dose and see if the combination can shrink tumors. About 55 adults with these…

This study tests whether eating a controlled low-calorie diet before chemotherapy can reduce side effects like fatigue, nausea, and mouth sores, and also improve how well the treatment works. About 130 adults with breast or prostate cancer will be randomly assigned to either foll…

This study compares two physical therapy methods for children aged 8 to 24 months who have or are at high risk for cerebral palsy. One method focuses on sitting, reaching, and problem-solving, while the other focuses on general motor skills. The goal is to see which approach bett…

This study looks at whether using virtual reality (VR) can lower pain and anxiety in cancer patients who need a bone marrow biopsy or lumbar puncture. About 60 participants will use VR during the procedure and report their pain and anxiety levels. The goal is to see if this simpl…

This study is testing a new bilingual web tool to help people with chronic sinusitis decide between surgery and other treatments. About 50 patients will use the tool or receive standard information. The goal is to see if the tool helps patients make choices that better match thei…

This study looks at how colorectal cancer affects the physical and emotional health of adolescents and young adults (ages 18-39). Researchers will measure symptoms like fatigue, pain, and anxiety, as well as physical fitness, to better understand the challenges these patients fac…

This study compares using stitches (nylon sutures) versus metal staples to close surgical wounds after leg fracture surgery. The goal is to see which method leads to fewer infections and to test if a larger study is possible. About 50 adults with certain leg fractures will be ran…

This long-term study follows 1,500 volunteers with normal memory, mild cognitive impairment, or Alzheimer's to track how the disease progresses. Researchers use brain scans, memory tests, and genetic data to better understand Alzheimer's and improve future clinical trials. The st…

This study planned to test a special vacuum dressing on surgical wounds after lower leg amputation. It aimed to see if the dressing reduced swelling, helped people walk sooner, and was more comfortable than standard bandages. The study was withdrawn before any participants were e…

This study looks at whether music lessons can improve brain development in children ages 6 to 8. About 114 kids from Los Angeles will be randomly placed in either a music program or an after-school arts program for 24 months. Researchers will use brain scans and behavior tests to…

This study uses a very powerful 7 Tesla MRI scanner to take detailed pictures of the brain in testicular cancer patients who have low testosterone (hypogonadism) and are receiving testosterone replacement therapy. The goal is to see if this advanced imaging can detect changes in …