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New combo therapy aims to boost immune attack on kidney cancer

NCT ID NCT03092856

First seen Jan 05, 2026 · Last updated May 21, 2026 · Updated 23 times

Summary

This study tests whether adding an experimental drug (anti-OX40 antibody) to a standard targeted therapy (axitinib) can help control advanced kidney cancer that has spread. About 62 adults whose cancer worsened after prior immunotherapy will receive either the combination or axitinib alone. The goal is to see if the combination delays cancer growth and is safe.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Cleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer Center

    Cleveland, Ohio, 44195, United States

  • Los Angeles County-USC Medical Center

    Los Angeles, California, 90033, United States

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio, 43210, United States

  • USC / Norris Comprehensive Cancer Center

    Los Angeles, California, 90033, United States

  • USC Norris Oncology/Hematology-Newport Beach

    Newport Beach, California, 92663, United States

  • University of California Davis Comprehensive Cancer Center

    Sacramento, California, 95817, United States

  • University of Kansas Cancer Center

    Kansas City, Kansas, 66160, United States

  • University of Pittsburgh Cancer Institute (UPCI)

    Pittsburgh, Pennsylvania, 15232, United States

  • University of Virginia Cancer Center

    Charlottesville, Virginia, 22903, United States

  • Weill Cornell Medical College, New York- Presbyterian Hospital

    New York, New York, 10065, United States

Conditions

Explore the condition pages connected to this study.