University Of Cologne

This study tests whether the drug dapagliflozin (a type of SGLT2 inhibitor) can slow the loss of kidney function in people with autosomal dominant polycystic kidney disease (ADPKD), a common genetic cause of kidney failure. The trial will enroll 420 adults aged 18 to 60 with rapi…

This study looks at how different diets—like a fasting-mimicking diet, a ketogenic diet, or a diet low in certain amino acids—change the biology of kidney tissue in living donors. About 80 donors will follow one of these diets for a short time before their scheduled kidney donati…

This study watches how the body manages water and salt levels in people being treated for low blood sodium (hyponatremia). Researchers will track 50 adults to see how fluid and electrolyte levels change over time. The goal is to better understand the treatment process, not to tes…

This study looks at how well vaccines against respiratory viruses (like flu and COVID-19) work in people with weakened immune systems. Researchers will track 1,000 adults who are either immunocompromised due to illness or treatment. The goal is to measure both antibody and T-cell…

This study creates a registry to collect information from 200 people with hantavirus infections worldwide. Researchers aim to describe how often the disease occurs, its complications, and what treatments are used. No new therapy is tested; the goal is to gather knowledge to impro…

This study is a registry that collects information from up to 2,000 adults with ADPKD who are being considered for or already taking tolvaptan. Researchers will track how the drug is dosed, how long people stay on it, and how their kidney function changes over time. The goal is t…

This study creates a global registry for leptospirosis, a bacterial disease caught from animals or contaminated water. Researchers will collect information from 200 people to track how often the disease occurs, what treatments work, and how the bacteria change. No new treatments …

This study looks at whether placing a moderate or late preterm baby directly on the mother's skin right after vaginal birth can reduce stress and improve development. Researchers will compare babies who get immediate skin-to-skin contact with those who are separated briefly. The …

This study looks at how people with end-stage kidney disease manage sodium levels when given extra water or salt. Researchers want to test if current theories about sodium balance hold true in these patients. The goal is to better understand hyponatremia (low sodium), a common an…