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New study tracks fluid and salt balance to improve low sodium treatment

NCT ID NCT05692726

Knowledge-focused Sponsor: University of Cologne Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study is observing 50 adults with low sodium levels (hyponatremia) who are receiving standard hospital treatment. Researchers will measure changes in blood and urine sodium, body water, and weight over the first five days. The goal is to better understand how the body balances fluids and electrolytes during treatment, which could lead to improved care in the future.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help doctors better understand how to treat low sodium levels, leading to safer and more effective treatment guidelines.
What could go wrong
This is a small observational study (50 people) that does not test a new treatment. It only measures what happens during standard care, so it cannot prove any new therapy works.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2022

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with non-hypervolemic hyponatremia

Ages

18 years and older

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients ≥ 18 years * Hypotonic hyponatremia * glucose-corrected plasma sodium \<130 mmol/l * serum osmolality \<280 mosmol/kg or lack of signs of non-hypotonic hyponatremia Exclusion Criteria: * Signs of extracellular volume expansion * Patients with liver cirrhosis and severe liver damage AST/ALT\>3xULN, AP\>6xULN, Bilirubin ≥ 3mg/dl * Patients with heart failure * Patients on dialysis and/or patients with oliguric renal impairment and plasma creatinine ≥ 3mg/dl * Patients after organ transplantation

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Conditions

The condition(s) this trial relates to.

Hyponatremia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Non-hypervolemic hyponatremia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University Hospital of Cologne

    RECRUITING

    Cologne, 50937, Germany