University Of British Columbia

This study aims to find the best surgical approach for people with early oral cancer or pre-cancerous lesions that have a specific genetic change (p53 mutation). Researchers will compare different surgery strategies across three groups of patients to see which approach best preve…

This study is testing whether a non-invasive brain stimulation technique called iTBS can help reduce depression symptoms in young women. It will involve 8 female participants aged 16-24 who are currently experiencing depression. The approach aims to stimulate brain activity in ar…

This study aims to find out if using absorbable stitches (which dissolve over time) is as good as permanent stitches for repairing small umbilical hernias. It will involve over 900 adults having elective surgery for hernias 2 cm or smaller. The main goal is to see if the hernia i…

This study is testing whether combining two types of safe, non-invasive stimulation—one to the brain and one to the spinal cord—can help improve arm and hand function in people with chronic spinal cord injuries in the neck. Twenty-four participants will receive either the combine…

This trial aims to find the best way to manage atrial fibrillation (AFib) in people who also have heart failure. It will compare two main approaches: using catheter-based procedures to restore normal heart rhythm versus using medications and devices to control the heart rate. The…

This study aims to see if giving dentists personalized reports about their opioid prescribing habits, along with educational materials, can help reduce unnecessary opioid use for dental pain. It will involve nearly 3,500 dentists in British Columbia, Canada. Researchers will comp…

This study is testing whether new ways to program deep brain stimulation (DBS) devices can help people with essential tremor who stopped responding to their standard DBS therapy. Five participants will try six different stimulation patterns in clinic, then use one at home for thr…

This study is testing if a specific diet plan can make a standard Crohn's disease medication work better for children. Researchers will compare children taking the drug alone to those who also follow the special diet. The goal is to help kids achieve better disease control, reduc…

This small, early-stage study is testing a new non-invasive neck device designed to help control breathing during sleep. Researchers will have 10 healthy participants wear the device at home to see if it safely reduces breathing pauses and is comfortable to use. The goal is to ga…

This study is testing a new type of ultrasound scan to see if it can accurately measure fat, stiffness, and inflammation in the liver. Researchers will compare the new ultrasound results to standard MRI scans and biopsy reports in 145 volunteers, including healthy people and thos…

This study aims to see if a single, low dose of the medicine indomethacin, given soon after birth, can safely prevent severe brain bleeds in babies born extremely early (before 26 weeks). Researchers will compare it to a placebo (saltwater) in up to 500 babies across multiple cou…

This study is testing whether a 6-month online educational program called Brain Health PRO can help people at risk for dementia improve their lifestyle habits. Researchers will enroll 700 Canadian adults aged 50-80 who have risk factors like family history, high blood pressure, o…

This small pilot study is testing whether a special device called 'Calmer' can help support brain development in very premature babies. The device mimics a parent's touch, heartbeat sounds, and breathing motion to reduce stress when parents cannot be present. Researchers will use…

This study aims to find out if teens with eczema prefer to apply moisturizer while still in the shower or bath, or after they have towel-dried. Researchers will compare both methods over two months to see which one feels better and if it makes a difference for skin hydration and …

This study aims to see if giving family doctors and nurse practitioners personalized feedback about their antibiotic prescribing habits helps reduce unnecessary prescriptions. Over 7,600 healthcare providers in British Columbia will be randomly assigned to receive this educationa…

This study aims to determine how much phenylalanine (an essential amino acid from food) healthy women need during different phases of their menstrual cycle. Current nutrition guidelines are based on research done only in men and may not be accurate for women. Researchers will use…

This study aims to understand how the sex hormones estrogen and testosterone directly control blood flow to the brain. Researchers will temporarily block and then restore these hormones in 50 healthy young men and women to measure changes in brain blood flow and oxygen use. The g…

This study aims to understand what sensations women experience during planned C-sections performed with spinal anesthesia. Researchers will ask 310 participants about their feelings at specific moments during surgery and follow up for six months to see how these experiences affec…

This study aims to understand how the bacteria in a pregnant woman's gut and her diet might influence inflammation in her baby's gut after birth. Researchers will follow 80 pregnant women, some with and some without Inflammatory Bowel Disease (IBD), and their babies for a year. T…

This study aims to learn if performing back exercises with your arm fully overhead versus at shoulder level leads to more muscle growth. Twenty young, healthy adults who already lift weights will train one arm with each method for 12 weeks. Researchers will use MRI scans and stre…

This study aims to understand how much leucine, an essential protein building block, healthy pregnant women need during early and late pregnancy. Researchers will measure how the body uses leucine by having 40 participants eat carefully prepared meals and provide breath, urine, a…