University Of Birmingham

This study tests whether a fecal microbiota transplant (FMT) can help people with primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD). About 58 adults will receive either FMT or a placebo. The goal is to see if FMT can lower liver enzyme levels and improve s…

This study tests whether adding a cannabis-based mouth spray (Nabiximols) to standard chemotherapy can help people with a returning, aggressive brain tumor called glioblastoma live longer. About 120 adults whose tumor has returned after initial treatment will be randomly assigned…

This study is for people with relapsed or refractory follicular lymphoma, a type of blood cancer that has come back or not responded to treatment. It compares new experimental therapies to the current standard treatment to see which works better. About 284 adults will take part, …

This study is for people with blood cancers like leukemia or lymphoma who need a stem cell transplant from an unrelated donor. It compares two ways to prevent graft-versus-host disease (GVHD), a serious complication where donor cells attack the patient's body. One method uses a d…

This study tests whether the drug ruxolitinib works better than standard treatments (interferon or hydroxycarbamide) for people with high-risk polycythemia vera, a blood cancer that causes too many red blood cells. About 586 adults aged 18 and older with high-risk features will b…

This study is for children and young people with B-cell non-Hodgkin lymphoma that has come back or not responded to treatment. Current treatments cure only about 30% of these patients and have severe side effects. The trial will test several new medicines, alone or with chemother…

This study tests new combinations of drugs for children and young adults whose neuroblastoma has come back or not responded to standard treatment. About 160 participants will receive one of three treatment regimens to see which works best and is safest. The goal is to improve sur…

This study compares two common surgeries—CSF shunting and dural venous sinus stenting—to see which better preserves vision in adults with idiopathic intracranial hypertension (IIH) at risk of blindness. About 80 participants will be randomly assigned to one procedure and followed…

This study looks at whether drinking whey protein before meals can help older adults (ages 75-90) with type 2 diabetes keep their blood sugar levels steadier throughout the day. Over two 7-day periods, participants will take either a whey protein drink or a placebo before each me…

This study tests a group therapy program (GTEP) for people who had a traumatic birth. Ten participants will attend online sessions and report changes in trauma symptoms, wellbeing, and bonding with their baby. The goal is to see if this approach is feasible and helpful.

This study aims to improve how brain tumors (gliomas) are diagnosed and treated by using advanced genetic testing. Researchers will build a network of UK hospitals to quickly analyze each tumor's unique genetic makeup. The goal is to match patients with targeted therapies that wo…

This study looks at whether eating grapes rich in natural compounds called flavonoids can protect brain function, blood vessel health, and mood during mental stress in healthy young adults. Researchers will give 44 participants either high-flavonoid grape powder or a low-flavonoi…