University Hospital Southampton Nhs Foundation Trust

This early-phase study tests a new combination of three drugs (radioactive therapy, an immunotherapy, and a checkpoint inhibitor) in children whose neuroblastoma has come back or is hard to treat. The main goal is to see if the combination is safe and tolerable. About 44 children…

This study tests whether giving a single dose of radiation directly to the tumor area during surgery is feasible for people with advanced or recurrent rectal cancer. About 31 participants will be randomly assigned to receive standard surgery alone, or surgery plus one of two radi…

This study tests whether adding the targeted drug acalabrutinib to standard chemotherapy (R-CHOP) helps people with untreated diffuse large B-cell lymphoma live longer without the cancer growing. About 450 adults will receive one cycle of R-CHOP, then two-thirds will also take ac…

This study is testing a new way to look at brain scans, called Cortical Disarray Measurement (CDM), to see if it can help doctors better diagnose Alzheimer's disease. Researchers will follow 400 people with mild memory or thinking problems over time, comparing CDM results with st…