University Hospital, Angers

This study compares two ways of organizing care for people with primary liver cancer who receive artery-based treatments like chemoembolization or radioembolization. It tests whether patients can safely and comfortably receive their treatment and recover at home (outpatient care)…

This study aims to see if closely monitoring the amount of a cancer drug (pembrolizumab) in a patient's blood can help doctors use it more effectively. It will involve 75 adults with non-small cell lung cancer who are already receiving this treatment. Researchers will check if sp…

This study is testing whether starting personalized nutrition support within two days of a severe stroke can help reduce deaths in the first month. In the test group, a dietitian will assess each patient and create a feeding plan, which may include special foods or tube feeding i…

This study is testing a treatment called extracorporeal phototherapy (ECP) for people with chronic kidney transplant rejection. ECP involves taking a patient's blood cells, treating them with ultraviolet light, and returning them to the body to calm the immune system. Researchers…

This study is testing whether using a simple early warning system can help patients with serious blood cancers like leukemia and lymphoma. The system uses regular checks of vital signs (like heart rate and breathing) to identify patients at high risk of dangerous complications. I…

This study is testing if a more coordinated care plan helps people with persistent or recurring low back pain. It involves 500 working adults in France. The goal is to see if better teamwork between a person's doctor, physical therapist, and workplace health service improves reco…

This study aims to find the best timing for putting critically ill patients with severe breathing failure on a ventilator. It will compare a 'liberal' strategy (using the ventilator earlier) with a 'restrictive' strategy (trying to avoid it longer) in 200 adult patients. The goal…

This study aims to find out if a new, automated way of using a common blood test (called FIB4) is a good method for screening the general population for advanced liver scarring (fibrosis). The goal is to identify people with serious liver damage early, before they develop life-th…

This study is testing a detailed brain mapping technique to better predict which children with severe, medication-resistant epilepsy will become seizure-free after surgery. It will involve 120 children who are already being considered for surgery. The goal is to use this new scan…

This study is testing whether special MRI scans can accurately diagnose an aggressive form of fatty liver disease called NASH. Currently, doctors must perform a painful liver biopsy to confirm NASH. Researchers will compare MRI results from 60 adults with biopsy results to see if…

This study aims to find the best non-invasive testing strategy to diagnose advanced liver scarring (fibrosis) in people with fatty liver disease (NAFLD). Researchers will compare two different step-by-step approaches that combine simple blood tests with specialized scans to accur…

This study is testing a new care pathway for people with knee sprains. It compares using a quick, automated knee stability test (ADL) right after an emergency room visit to the standard approach of waiting for an MRI scan. The goal is to see if this faster diagnosis method leads …

This study aims to find the best way to prevent dangerous blood clots in people with serious leg injuries that require a cast or brace. Researchers are comparing a daily pill (rivaroxaban) against daily injections (low-molecular-weight heparin) in over 1,400 high-risk patients. T…

This study is testing whether adding immersive virtual reality (VR) to standard occupational therapy helps people with chronic upper limb pain. Twelve participants will use a VR headset during their therapy sessions to see if it improves their arm function and reduces pain. The g…

This study is testing whether regular karate practice can improve the mental health and quality of life of medical students, who often experience high stress and anxiety. Researchers will enroll 90 students from the University of Angers to see if karate helps with self-esteem, sl…

This study is testing whether specially designed video games that combine physical movement with mental challenges can help people with Huntington's disease. Researchers will compare two different exercise programs in 40 participants to see if they improve balance, walking, memor…

This study is testing a new home-based walking program that uses a special treadmill and virtual reality games. It aims to help children with conditions like cerebral palsy, neuromuscular diseases, or obesity improve their walking ability, strength, and overall quality of life. T…

This study aims to understand a rare, inherited disease called pseudoxanthoma elasticum (PXE) by looking at the eyes. Researchers will use a non-invasive eye scan to compare blood flow in the back of the eye between 60 healthy volunteers and 60 people with PXE. The goal is to fin…

This study aims to see if tracking the amount of a specific gene mutation (CALR) in a patient's blood over time can help doctors predict how their blood cell disorder will progress. It will follow 260 adults with these disorders for up to three years, collecting blood samples to …

This study aims to find out if the amount and characteristics of gas a patient passes after abdominal surgery can help predict their recovery and risk of complications. Researchers will enroll 200 adults having planned abdominal surgery and ask them to track their gas and stool p…

This study aims to find early warning signs in the blood that can predict if a child's rare autoimmune brain disease will relapse. Researchers will analyze blood samples from 20 children who have had a first attack of the disease. The goal is to discover biological markers that c…

This study aims to see if measuring oxygen levels in urine can help doctors predict when critically ill patients in shock might develop kidney failure. Researchers will monitor 55 patients in intensive care, some in shock and some not, by placing a special sensor in their urinary…

This study aims to learn how a specific type of immune cell, called a monocyte, behaves in people with certain blood cancers. Researchers will collect blood samples from 70 participants who have not yet started treatment for their condition. By analyzing these cells, they hope to…

This study aims to discover biological markers that can predict which patients with certain blood cancers will respond well to standard first-line treatments. Researchers will analyze blood samples from 120 adults with polycythemia vera, essential thrombocythemia, or pre-myelofib…

This study is testing a new picture-based questionnaire called PETRA. It aims to better measure how often people with shoulder and arm pain avoid everyday tasks, like reaching or throwing. Researchers will give the questionnaire to 200 adults being evaluated for a specific type o…

This study aims to see if training emergency room doctors in how to announce an early miscarriage improves the psychological experience for patients. It will involve 1,000 women who experience a pregnancy loss before 14 weeks. The main goal is to measure if this specific communic…

This study aims to better understand a specific genetic mutation (ASXL1) found in a blood cancer called myelofibrosis. Researchers will observe 50 adult patients over 4 years to see how different patterns of this mutation relate to survival and the risk of the disease worsening. …

This study aims to test a new, simpler questionnaire designed to measure how physically active people are. Researchers will compare answers from the new questionnaire with data from a wearable activity monitor worn by 118 participants from the general public. The goal is to see i…

This study aims to understand how common immediate food reactions are in children with eosinophilic esophagitis (EoE). Researchers will observe 40 children aged 6-18 who experience throat pain, pressure, or choking within minutes of eating certain foods. The goal is to gather inf…

This study aims to understand how Amyotrophic Lateral Sclerosis (ALS) affects social cognition—the ability to recognize emotions in faces and voices. Researchers will compare 74 French-speaking ALS patients to healthy volunteers using specific movie-based tests. The goal is to ga…

This study aims to understand if adding specific nutrients to blood cells can fix their energy production in patients with septic shock, a severe infection causing organ failure. Researchers will take blood samples from 55 patients in intensive care and test the cells in a lab. T…

This study aims to understand why women tend to have worse recovery and higher risk of heart failure after a heart attack compared to men. Researchers will follow 1,650 people for up to 10 years, using heart imaging scans to track how the heart's size and shape change over time. …

This study aims to understand how living in extreme isolation for long periods affects human health, specifically the immune system. Researchers will follow 9 healthy young adults spending a year at a remote French research station on the Kerguelen Islands. They will collect bloo…

This study aims to understand if and how a group of rare, inherited movement disorders called spinocerebellar ataxias (SCA) affect a person's social skills. Researchers will recruit 160 people, including patients with specific SCA types and healthy volunteers, to complete various…

This study aims to understand how two different types of ARDS (Acute Respiratory Distress Syndrome) affect how the lungs use oxygen when different pressure levels are set on a breathing machine. Researchers will observe 50 sedated patients on ventilators in France, using a specia…

This study aims to understand how chemotherapy affects memory, concentration, and thinking skills in people being treated for blood cancers like leukemia and lymphoma. Researchers will compare 120 cancer patients to a control group of their relatives, using questionnaires and thi…