Tufts Medical Center

This phase 2 trial is testing whether a targeted antibody-drug conjugate called sacituzumab tirumotecan, given alone or together with the immunotherapy pembrolizumab, can shrink tumors in people with ovarian clear cell carcinoma that has returned after prior immunotherapy. The st…

This study tests a drug called veverimer in 60 adults aged 50 and older with osteopenia (low bone density). The goal is to see if lowering acid levels in the body can reduce bone breakdown. Participants take the drug or a placebo daily or every other day for 8 weeks, with 8 clini…

This study looks at whether adding protein supplements to the diet can prevent muscle wasting in people with heart failure. About 120 adults with heart failure and reduced pumping ability will be randomly assigned to receive no, low, or high doses of protein drinks. The main goal…

This study tests whether using a special heart monitor (pulmonary artery catheter) early in the hospital can lower the risk of death for people in cardiogenic shock caused by heart failure. About 400 adults with severe heart failure and shock will be randomly assigned to get eith…

This study tests whether wearing a continuous glucose monitor that shows real-time blood sugar levels on a smartphone app, plus joining a group chat with other pregnant women, helps keep glucose levels healthy during pregnancy. About 70 pregnant women at risk for gestational diab…

This study tests whether taking weekly vitamin D supplements, with doses adjusted to reach a target blood level, can help control blood sugar in 100 adults aged 30-74 who have prediabetes (high risk for type 2 diabetes). Participants are randomly assigned to receive vitamin D or …

This trial tests whether remote tai chi, taught through web-based sessions twice a week for 12 weeks, can reduce knee pain in adults aged 50 and older with knee osteoarthritis. Researchers compare adding remote tai chi to routine care against routine care alone, measuring pain, p…

This study looks at whether listening to music for 10 minutes during labor can lower anxiety and pain and improve satisfaction. About 106 women in labor will either listen to music or not. They will rate their anxiety and pain levels and answer questions about their care.

This study looks at how well a type of breast cancer surgery called oncoplastic breast surgery works over the long term. Researchers will review medical records and survey 1,500 women about their satisfaction, cancer recurrence, and complications. The goal is to learn which surgi…

This study looks at whether people who have a blood clot in the lungs (pulmonary embolism) are more likely to have a stroke if they also have a small hole in their heart (called a PFO). About 1 in 4 people have this hole, which can let a clot travel to the brain. Researchers will…