Thomas Jefferson University

This early-stage trial aims to find the safest, highest dose of radiation for treating aggressive or returning meningioma brain tumors. Researchers will use advanced PET and MRI scans to precisely guide the radiation to the tumor. The study will enroll 24 adults to test four diff…

This early-stage study is testing the safety and best dose of a three-drug combination for patients with follicular or marginal zone lymphoma that has come back or not responded to prior treatment. The drugs—venetoclax, lenalidomide, and rituximab hyaluronidase—work together to h…

This study is testing a new combination of three drugs—navitoclax, venetoclax, and decitabine—for patients with a high-risk type of blood and bone marrow cancer called myelodysplastic syndrome (MDS) that has come back or hasn't responded to standard treatments. The main goals are…

This study is testing whether a phone-based coaching program can help men on hormone therapy for prostate cancer. Participants work with a coach to gradually extend their overnight fasting period, aiming for 16 hours each night, and report their progress via text messages. The go…

This study is testing whether N-acetyl cysteine (NAC), an antioxidant supplement, can help protect brain function in people with multiple sclerosis (MS). Researchers will use brain scans to measure changes in brain metabolism and inflammation in 55 MS patients who receive either …

This early-stage trial is testing whether combining three different treatments is safe for men with aggressive prostate cancer. The approach uses a hormone-blocking drug (enzalutamide), radiation therapy, and standard hormone injections to attack the cancer from multiple angles. …

This study is testing whether a special type of ultrasound can accurately find prostate cancer. The ultrasound uses a safe, short-lived contrast agent to make images clearer. Researchers will compare the ultrasound results with tissue from patients' prostate surgeries to see how …

This study is testing a new wearable neck sensor designed to catch dangerous breathing slowdowns caused by opioid painkillers after surgery. Researchers will compare the sensor's readings to standard hospital monitors on 120 patients to see if it can accurately detect and even pr…

This study compares three different pain management approaches for adults aged 55+ with multiple broken ribs. Researchers want to see which method best reduces pain and opioid use while helping patients breathe better. The trial involves 24 hospitalized patients who will receive …

This study is testing whether two dietary supplements—a ketone supplement and hawthorn extract—can help improve heart function and exercise ability in people with congestive heart failure. About 45 participants will be randomly assigned to take one of the supplements or a placebo…

This study is testing whether gentle electrical and magnetic stimulation applied to the skin over the spine can help improve movement and reduce muscle stiffness in people with long-term spinal cord injuries. Researchers will work with 10 participants to find the best stimulation…

This study is testing whether a special earbud device, which gently stimulates a nerve in the ear, can help reduce anxiety and emotional distress in healthcare workers. Researchers will enroll about 90 stressed healthcare professionals from Philadelphia to use the device for thre…

This study is testing a new web-based tool called a 'virtual genetics board' for doctors and other healthcare providers. The goal is to see if this online meeting space is useful for discussing complex prostate cancer genetics cases, treatment options, and screening recommendatio…

This study aimed to understand how surgery and other treatments for head and neck cancer affect a patient's sleep quality over time. Researchers planned to survey patients at different points in their treatment and recovery to identify factors that disrupt sleep. The goal was to …

This study aims to understand how stress, depression, and social factors might affect liver disease progression in Korean Americans living with chronic hepatitis B. Researchers will follow 365 participants over time, collecting health information and hair samples to measure stres…

This study aims to understand what helps or prevents people from getting screened for colorectal cancer, particularly in African American, Latinx, and Chinese communities. Researchers will conduct interviews and group discussions to learn about cultural beliefs and knowledge gaps…