Sunnybrook Health Sciences Centre

This study tests whether mindfulness-based therapy can help people with obsessive-compulsive disorder (OCD). Researchers will compare mindfulness to standard cognitive behavioural therapy (CBT) in 420 adults with OCD. The goal is to see if mindfulness reduces OCD symptoms and to …

This phase II trial tests whether adding the targeted drug acalabrutinib to standard chemotherapy (bendamustine and rituximab) improves outcomes for people with untreated Waldenstrom's macroglobulinemia, a rare blood cancer. About 63 participants will receive the three-drug combo…

This study tests whether giving inhaled anesthetics (isoflurane or sevoflurane) to sedate COVID-19 patients on ventilators can improve survival and reduce time on the breathing machine compared to standard IV sedatives. About 800 adults in ICUs who need a ventilator will be rando…

This study tests whether a drug called QBECO, given as a self-injection before and after liver surgery, can lower the chance of colorectal cancer coming back or spreading. About 115 adults with colorectal cancer that has spread to the liver will take part. They will inject the dr…

This study tests a higher dose of radiation given over 3 weeks for people aged 65 and older with glioblastoma or a similar aggressive brain tumor. The treatment uses daily MRI scans to adjust the radiation beam precisely to the tumor. The goal is to improve how long the cancer st…

This study compares lung ultrasound performed by medical trainees to standard chest X-rays for detecting pneumothorax (collapsed lung) after chest tube removal in heart surgery and trauma patients. Researchers will enroll 60 adults to see if the ultrasound method is accurate and …

This small pilot study tests whether giving a brief, non-invasive brain stimulation (rTMS) before cognitive behavioral therapy (CBT) can help people with obsessive-compulsive disorder (OCD) get better results. Ten adults with OCD will receive rTMS to improve thinking skills like …

This study tests a laser treatment for post-menopausal women suffering from vaginal dryness, itching, pain during sex, and urinary discomfort. About 60 women aged 45-70 will receive the laser therapy to see if it eases their most bothersome symptom. The goal is to provide an alte…

This study tests whether watching immersive 360-degree videos through a VR headset can reduce pain, anxiety, and the need for strong painkillers during dressing changes after burn surgery. About 80 adults who had skin grafts for burns will use VR during two dressing changes and r…

This study tests whether watching a virtual reality (VR) video of an electroconvulsive therapy (ECT) session can reduce anxiety and improve knowledge about the procedure. About 64 adults about to have ECT for the first time will be randomly assigned to either a VR education sessi…

This study tests whether watching a 30-minute online video before hip or knee replacement surgery can help patients use fewer opioids afterward. The video teaches safe use of painkillers and coping techniques. About 220 adults are taking part, and researchers will track how much …

This study tests whether magnetic stimulation of the pelvic floor can help women with stress urinary incontinence (leaking urine when coughing, sneezing, or exercising). About 158 adult women will receive the treatment and report their symptoms using questionnaires. The goal is t…

This study tests whether a laser applied to the vagina can help women with stress urinary incontinence (leaking urine when coughing, sneezing, or exercising). About 144 women will receive the laser treatment and be followed for 6 months. The main goal is to see if the treatment r…

This study compares virtual reality (VR) training to mannequin training for teaching medical students how to manage airway injuries. Forty medical students will be randomly assigned to learn using VR or a mannequin, then tested a week later. The goal is to see if VR can provide e…

This study looks at two types of radiation for people with 5 to 30 brain tumors that have spread from other cancers. One group gets focused radiation (SRS) alone, the other gets whole-brain radiation plus SRS. The main goal is to see which approach better protects memory and thin…

This study looks at two ways to help people in the ICU who have trouble breathing due to low oxygen levels. It compares using a helmet-like device plus high-flow oxygen through the nose versus high-flow oxygen alone. The goal is to see which approach works better and to gather in…

This long-term study uses yearly brain scans, genetic tests, and thinking/memory assessments to track changes in nearly 1,800 people with various dementias (like Alzheimer's and vascular dementia) and over 140 healthy older adults. The goal is to better diagnose, monitor, and eve…

This observational study looks at how often a small tube that delivers pain medicine near the knee (called an adductor canal catheter) stays in the right place the day after total knee replacement. About 100 people over age 50 having knee surgery will be checked with ultrasound t…