Sunnybrook Health Sciences Centre

This study tests a new radiation method for people 65 and older with glioblastoma, a fast-growing brain tumor. Instead of the usual lower dose, patients receive a higher dose over 3 weeks using a special machine (MR-Linac) that takes daily MRI scans to adjust the radiation precis…

This study tests a new drug, acalabrutinib, added to standard chemotherapy for people with untreated Waldenstrom's macroglobulinemia, a rare blood cancer. About 63 participants will receive the combination for up to a year. The goal is to see if this approach improves response ra…

This study looks at whether giving COVID-19 patients on breathing machines a sedative gas (instead of standard IV drugs) helps them recover faster and survive more. About 800 adults in the ICU will be randomly assigned to receive either the inhaled gas or standard IV sedation. Th…

This study tests whether a medication called QBECO, given as self-injections before and after liver surgery, can lower the chance of colorectal cancer coming back or spreading. About 115 adults with colorectal cancer that has spread to the liver will take part. They will inject Q…

This study tests a laser treatment to relieve vaginal symptoms like dryness, itching, and pain during sex caused by menopause. About 60 women aged 45-70 with moderate or severe symptoms will receive the laser therapy. The goal is to see if it improves their most bothersome sympto…

This study tests whether watching a virtual reality (VR) video of an ECT session can lower anxiety and improve understanding in people about to have ECT for the first time. About 64 participants will be randomly assigned to either view the VR video or have a standard talk with th…

This study tests whether a non-invasive magnetic stimulation device can strengthen pelvic floor muscles and reduce or stop stress urinary incontinence in women. About 158 adult women with confirmed stress incontinence will receive the treatment. The goal is to see if it can provi…

This small pilot study tests whether a brief, non-invasive brain stimulation technique called rTMS can boost the effects of cognitive behavioral therapy (CBT) for people with obsessive-compulsive disorder (OCD). Ten adults with moderate to severe OCD will receive rTMS before star…

This study tests whether a short-term mindfulness program can reduce the distress of obsessive-compulsive disorder (OCD) in 420 adults. Participants receive either mindfulness therapy or standard treatments like cognitive-behavioral therapy. The goal is to see if mindfulness offe…

This study looks at whether small tubes that deliver pain medicine near the knee (adductor canal catheters) stay in the right place the day after total knee replacement. Researchers will check 100 patients over age 50 to see how often the catheters move and what might cause them …

This study looks at two types of radiation for people with 5 to 30 brain tumors that have spread from other cancers. One group gets focused radiation (SRS) alone, and the other gets focused radiation plus whole-brain radiation. The goal is to see which approach better protects me…

This study compares virtual reality (VR) training to traditional mannequin training for teaching medical students how to manage airway injuries. About 40 medical students will be randomly assigned to learn using VR or a mannequin, then tested a week later. The goal is to see if V…