Sunnybrook Health Sciences Centre

This study tests whether a single infusion of eptinezumab, given within 8 weeks of a mild brain injury, can reduce headache days and prevent short-term post-traumatic headaches from becoming long-term. About 80 adults with migraine-like post-traumatic headaches will receive eithe…

This study tests whether a structured, goal-directed care plan can help people with diabetic kidney disease better manage their kidney and heart health. About 100 adults with type 2 diabetes and kidney disease will either receive this focused care or standard treatment. The goal …

This study tests whether regular blood tests (ctDNA) can find triple-negative breast cancer recurrence earlier than standard follow-up. Thirty patients who had surgery for stage II or III TNBC will be randomly assigned to either standard care or standard care plus ctDNA testing e…

This study tests whether adding a very low dose of the blood thinner edoxaban (15 mg daily) to standard antiplatelet therapy (aspirin or clopidogrel) can reduce the risk of another stroke in people aged 75 and older who have already had an ischemic stroke. About 1,200 participant…

This study tests whether adding a low-carb ketogenic diet to a non-invasive brain stimulation technique called iTBS can improve depression symptoms more than the brain stimulation alone. Sixty adults with treatment-resistant depression will follow either a keto diet or a standard…

This small pilot study tests whether adding virtual reality (VR) to standard ketamine infusions can better ease symptoms of treatment-resistant depression. All 31 participants will receive ketamine, and half will also wear a VR headset during treatment. The main goal is to see if…

This pilot study will test whether a non-invasive brain stimulation technique called transcranial alternating current stimulation (tACS) can improve working memory in 30 adults with mild cognitive impairment or traumatic brain injury. Participants will receive low-level electrica…

This study compares two ways of using ultrasound to measure the inferior vena cava, a major vein that shows how much fluid is in the body. The standard method uses a view below the breastbone, but this can be hard in patients who are obese or have surgical bandages. The alternati…

This study compares virtual reality (VR) simulation to traditional mannequin-based training for teaching medical students how to perform electroconvulsive therapy (ECT). 78 medical students with no prior ECT training will be randomly assigned to practice with either a VR simulato…

This study looks at whether reading a short educational flyer helps women learn more about stress urinary incontinence (SUI). About 90 adult women visiting a urogynecology clinic will fill out a quiz before and after reading the pamphlet. The goal is to see if the pamphlet improv…

This study looks at how different positions and positioning devices affect pressure on areas like the heels, tailbone, elbows, and back of the head in burn patients. Researchers will use a special pressure-sensing mat to find which setups create the least pressure. The goal is to…

This study looks at how paramedics give breaths during CPR to people whose hearts have stopped. Researchers want to find the best way to provide oxygen to improve chances of survival. About 1,656 adults will take part, and the study will track if better breathing techniques help …

This study aims to find the right dose of enzalutamide for men aged 75 and older with advanced prostate cancer. Researchers will measure drug levels in the blood to compare with younger patients. The goal is to improve treatment by reducing side effects while keeping the drug eff…

This study tests a new peer support program for adults recovering from serious injuries like car crashes, burns, or amputations. The program pairs survivors with trained peers who have been through similar experiences, offering support from hospital to home. The goal is to see if…