Sunnybrook Health Sciences Centre

This study tests whether a single infusion of eptinezumab, given within 8 weeks of a mild traumatic brain injury, can reduce the number of headache days and prevent headaches from becoming long-lasting. About 80 adults with post-traumatic headaches that feel like migraines will r…

This study tests whether adding a very low dose of the blood thinner edoxaban (15 mg daily) to standard aspirin or clopidogrel therapy can better prevent recurrent strokes in people aged 75 and older who have had an ischemic stroke. About 1,200 participants will be randomly assig…

This study tests whether adding a ketogenic diet to a type of brain stimulation (called iTBS) can better reduce symptoms in adults with depression that hasn't improved with standard treatments. Sixty participants will follow either a keto diet or a standard healthy diet for sever…

This small pilot study tests whether adding virtual reality (VR) to standard ketamine treatment helps adults with treatment-resistant depression feel better faster. All 31 participants will receive ketamine, and half will also use a VR headset during treatment. The main goal is t…

This study compares two ways of using ultrasound to measure the inferior vena cava, a large vein that shows how much fluid is in the body. The standard method uses a view below the breastbone, but this can be hard in patients who are obese or have surgical dressings. The new meth…

This study tests whether a blood test that looks for cancer DNA can find returning triple-negative breast cancer earlier than usual scans. Thirty people who finished treatment for stage II or III TNBC will be randomly assigned to standard follow-up or standard follow-up plus regu…

This study tests whether a peer support program—where people who have survived similar injuries offer guidance—is practical and helpful for trauma survivors. About 49 adults hospitalized after accidents, burns, or amputations will take part. The goal is to see if the program is f…

This study will follow 100 adults who need a chest tube after breaking their ribs. The goal is to learn how often people develop long-term nerve pain (intercostal neuralgia) from the procedure, what factors raise the risk, and how it affects daily life. Researchers will use pain …

This study looks at how paramedics give breaths during CPR to people whose hearts have stopped. Researchers want to find the best way to provide oxygen to improve chances of survival. About 1,656 adults will take part, and the study will track if better breathing techniques help …

This study looks at whether a short educational pamphlet can improve what women know about stress urinary incontinence (SUI). About 90 adult women visiting a urogynecology clinic will take a quiz on SUI, read the pamphlet, then take the same quiz again. Researchers will compare s…

This study compares virtual reality (VR) training to traditional mannequin-based training for medical students learning how to perform electroconvulsive therapy (ECT). About 78 medical students who have never received formal ECT training will be randomly assigned to practice with…