Shanghai Pulmonary Hospital, Shanghai, China

This study tests a drug called teniposide in people with a hard-to-treat type of lung cancer that has spread and has not responded to standard treatments. The cancer must have a specific gene change (c-Myc-driven). The goal is to see if the drug can shrink tumors and control the …

This study tests whether a combination of two drugs (sacituzumab tirumotecan and limertinib) can shrink locally advanced EGFR-mutant lung cancer enough to allow surgery. About 36 adults who have not had prior treatment will receive the drugs before surgery. The main goal is to se…

This study is for people with stage II or III non-small cell lung cancer that can be removed with surgery. Before surgery, participants will receive a combination of two immunotherapy drugs (sintilimab and IBI310) plus chemotherapy. The goal is to see if this treatment shrinks th…

This study tests whether a new drug called IBI363, combined with chemotherapy, can shrink stage III lung cancer that cannot be surgically removed. The goal is to make the cancer small enough for successful surgery. About 43 adults with this type of lung cancer will receive the tr…

This study tests whether combining the drug envolizumab with radiation therapy before surgery can safely shrink tumors in people with locally advanced thymic carcinoma. About 25 adults aged 18-75 who have not had prior treatment will receive the combination, then undergo surgery.…

This study compares two types of lung surgery for people with small lung cancers (≤2 cm). One surgery removes only a part of the lung lobe (segmentectomy), while the other removes the entire lobe (lobectomy). The goal is to see if the smaller surgery works just as well at prevent…

This study aims to see if a computer can create a synthetic PET image from a regular CT scan to help diagnose and treat lung cancer more accurately. Researchers will enroll 10,000 people with non-small cell lung cancer to compare the synthetic images with real PET scans. If succe…

This study compares a long-acting numbing medicine (liposomal bupivacaine) to a standard one for pain after lung surgery. About 210 adults having keyhole lung surgery will be randomly assigned to receive one of the two drugs or no nerve block. The goal is to see if the long-actin…

This study tests whether a newer drug, sugammadex, helps people breathe better right after lung surgery compared to an older drug, neostigmine. About 240 adults having a small part of their lung removed will be randomly assigned to receive one of the two drugs. The main goal is t…

This study looks at whether a lab-made model of a patient's own lung cancer cells can help doctors choose the most effective drugs. Researchers will compare the model's predictions with how the patient actually responds to treatment. The goal is to see if this approach can improv…

This study is for 1500 Chinese adults with bronchiectasis, a lung condition causing cough and infections. Researchers will analyze medical data and genetics to find different patient groups and disease patterns. The goal is to better predict outcomes and tailor treatments for eac…