Rhode Island Hospital

This study looks at whether the amount of tension applied to a new ACL graft during knee surgery influences the development of arthritis over at least 15 years. About 168 people with a torn ACL in one knee will be followed, comparing two common tension settings. The goal is to se…

This early study tests an implanted device called the Intelligent Spine Interface (ISI-C) in people with spinal cord injuries. The device is designed to bridge the gap in the spinal cord, picking up signals from above the injury and sending them to nerves below. The goal is to un…

This trial compares a disposable safety device called the Adult Sotair, which limits airflow, against standard manual ventilation in adults undergoing non-emergency surgery with general anesthesia. The goal is to see if the device helps keep airway pressures at safer levels. Thir…

This study tested two doses (40 vs 80 mg/kg) of praziquantel in 354 children aged 1-4 with schistosomiasis in Uganda. The goal was to find the best dose to cure the infection and improve growth and anemia. Currently, praziquantel is not approved for children under 4, and this tri…

This study tested whether DHEA, a natural hormone, can improve heart function in people with pulmonary arterial hypertension (high blood pressure in the lungs). 26 adults took DHEA or a placebo for 18 weeks, then switched. The main goal was to see changes in heart strain measured…

This study tests a counseling program called ACTPrEP, designed to help young Black men who have sex with men (ages 18-34) start and continue taking PrEP, a daily pill that prevents HIV. The program uses acceptance and commitment therapy to address thoughts and feelings that might…

This study tested a program called iDOVE2 for teens at risk of peer violence and mild-to-moderate depression. The program started with a brief session in the emergency department, followed by automated text messages designed to prevent violence and depressive symptoms. Researcher…

This trial investigates whether open-label placebos—pills that patients know contain no active drug—can reduce pain and opioid use in adults with chronic low-back pain. Participants take the placebo twice daily for 21 days and receive different types of explanations (such as a st…

This study tested whether giving lidocaine through an IV works as well as an ultrasound-guided nerve block for controlling pain after total knee replacement. 120 adults having knee surgery were randomly assigned to receive either IV lidocaine or a saline placebo (with the nerve b…

This study tested whether an ultrasound-guided nerve block (Serratus Anterior Plane Block) can improve pain, breathing, and coughing in emergency room patients with rib fractures. Forty adults with confirmed rib fractures received either the nerve block or usual care. Researchers…

This study tested a non-drug treatment called Personalized Integrated Chronotherapy (PIC) for depression during pregnancy and after childbirth. 120 pregnant women with major depression were randomly assigned to receive either usual care (medication or therapy) or PIC plus usual c…

This study looks at how changing sleep time affects the immune system and breathing in urban children with asthma. Researchers will ask some children to go to bed 90 minutes later for a week, while others keep their usual bedtime. They aim to understand if short sleep worsens ast…

This study tested a program called Guardians 4 Health, which teaches youth and adults in shooting sports clubs how to step in and prevent firearm injuries. Researchers worked with 4-H Shooting Sports Clubs across the U.S. to see if the program changed people's intentions to act s…