Northwell Health

This study tests a new way to treat aggressive brain cancers that have come back after standard therapy. It combines a targeted drug called cetuximab, given directly into the brain's blood vessels, with a second round of radiation. The goal is to see if this approach can safely s…

This early-phase trial tests a technique called PIPAC, which sprays chemotherapy directly into the abdomen as a fine mist, for people with pancreatic cancer that has spread to the lining of the belly. The goal is to see if adding this treatment to standard therapy is safe and tol…

This study looks at whether a lower dose of the drug venetoclax can be safely given to people whose acute myeloid leukemia (AML) is in remission. The goal is to reduce serious side effects like low white blood cell counts while still preventing the cancer from coming back. About …

This study tests a noninvasive device that gently stimulates a nerve in the ear to help children with steroid-resistant nephrotic syndrome, a kidney condition that doesn't respond to standard steroids. The goal is to see if this approach is safe, tolerable, and can reduce inflamm…

This study looks at using two devices together to help people with severe heart failure. One device measures pressure in the lung artery, and the other stimulates nerves to improve heart function. About 15 adults with NYHA Class III heart failure will be followed for over a year …

This early study tests a device that sends mild electrical pulses to the spinal cord and limbs to help people with paralysis or weakness from spinal cord injury, stroke, or other nerve damage. Up to 64 participants will attend up to 5 sessions per week for a year, performing task…

This study compares two levels of a special care program for Black and Hispanic pregnant women at high risk for severe complications. About 674 women will be randomly assigned to either a high-touch or low-touch version of the program early in pregnancy. The goal is to see which …

This study tests a new way of giving chemotherapy to people with metastatic pancreatic cancer. Instead of one standard regimen, patients will receive two different chemo combinations (NALIRIFOX and GnP) in alternating months. The goal is to see if this approach helps keep the can…

This study tests whether adding high-dose vitamin D to standard medication can help children aged 9–17 with newly diagnosed Graves' disease. About 30 participants will receive either vitamin D plus methimazole or methimazole alone. The main goal is to see if a larger trial is pos…

This early-phase study tests whether a new drug, Nelitolimod, can safely boost the immune system's ability to fight colorectal cancer that has spread to the liver. Ten adults will receive the drug directly into the liver through a special catheter before their scheduled surgery. …

This study tests whether deep brain stimulation (DBS) can help people with severe obsessive-compulsive disorder (OCD) who have not gotten better with medication or therapy. DBS uses a device implanted in the brain to send electrical pulses to areas linked to mood and anxiety. The…

This study looks at whether genetic markers and brain scans can help doctors choose the most effective medication for people experiencing their first episode of psychosis. Researchers will compare a standard antipsychotic to clozapine in 180 participants aged 18-35. The goal is t…

This study tests a drug called anakinra (Kineret) in people with Meniere's disease or autoimmune inner ear disease that hasn't responded to steroids. About 57 participants will receive either anakinra or a placebo for 42 days, with follow-up over several months. The goal is to se…

This early-stage study tests if deep brain stimulation (DBS) is safe and effective for people with depression that hasn't improved with other treatments. Twenty adults aged 18-65 with major depression or bipolar disorder will have a DBS device implanted. Their symptoms will be tr…

This study compares two treatments for bleeding after heart surgery: FEIBA (a drug that helps blood clot) versus fresh frozen plasma (standard care). About 140 adults having non-emergency heart surgery will be enrolled. The goal is to see if FEIBA reduces the need for blood trans…

This small pilot study is testing whether a gentle, non-invasive nerve stimulation device worn on the ear can help children with a frequently relapsing kidney disease. The goal is to see if this approach can reduce disease flare-ups and the need for strong steroid medications. Re…

This study is testing a new blood test that looks for tiny pieces of HPV DNA shed by cervical cancer or pre-cancer cells. The goal is to see if this simple blood draw can tell the difference between early pre-cancer and invasive cancer, and help monitor patients without needing r…

This study is testing whether a special MRI scan (called biparametric MRI) can improve prostate cancer screening for men at high risk, such as Black men or those with a family history of prostate cancer. The study will enroll 100 men with low PSA levels (between 1.0 and 2.5) to s…

This study tests whether doctors can use ultrasound through a special clear skull implant to see brain structures and detect problems after surgery. About 50 adults who are already getting this implant as part of their care will take part. The goal is to see if this method is acc…

This study tests an online program called StEP OUT that teaches healthy habits during pregnancy and infancy to prevent early childhood obesity in Latino families. About 130 pregnant women will either join group chats and video calls about healthy living or receive text messages w…

This study tests a minimally invasive procedure called radiofrequency ablation (RFA) for LatinX adults with benign thyroid nodules that cause discomfort or cosmetic issues. Instead of surgery, a thin needle uses heat to shrink the nodule. The goal is to see if RFA is safe and eff…

This study looks at whether a 10-day low-residue diet (low fiber) helps bowel function return to normal faster than a 6-week low-residue diet after elective colon surgery. About 222 adults having colon resection will be randomly assigned to one of the two diets. Participants will…

This study tests whether a non-invasive brain stimulation technique called TMS can improve brain function and thinking in people with schizophrenia. Forty adults aged 18–60 will receive either real or sham TMS daily for four weeks, alongside their usual care. Researchers will use…

This study tests a special catheter (Optrell) to treat heart rhythm problems coming from the papillary muscles. About 20 adults with frequent or bothersome extra heartbeats will be enrolled. The goal is to see if this catheter can map and eliminate the abnormal signals faster and…

This study tests a 10-week, at-home computer program called SCORES that uses brain exercises and group support to help teens at high risk for psychosis think faster and connect better with others. Researchers want to see if improving processing speed can boost social functioning …

This study is testing whether people with Diamond Blackfan anemia (a rare blood disorder) can produce enough stem cells in their blood to be collected for future gene therapy. Participants will receive two medications to stimulate stem cell release, and researchers will measure t…

This study looks at brain scans of 120 people experiencing their first episode of psychosis to see if certain brain connections can predict how well they will respond to standard antipsychotic medications like risperidone or aripiprazole. Participants receive treatment as usual f…

This study compares a mobile app called Always Uniquely Me (AUM) to standard care for people with intellectual and developmental disabilities who visit the emergency department. Researchers want to see if the app helps reduce the use of physical or chemical restraints and improve…

This study aims to understand why some people with Alzheimer's disease develop psychotic symptoms like delusions. Researchers will use brain scans to measure tau protein buildup and brain network changes in 91 older adults with and without psychosis, plus healthy volunteers. The …

This study looks at how well the Micra AV2 pacemaker tracks the heart's natural rhythm and detects hidden atrial fibrillation (an irregular heartbeat) in 50 people with a history of the condition. Participants will have their pacemaker checked regularly and may wear a special mon…

This study is for people starting a type of cancer drug called BTK inhibitors, which can sometimes cause irregular heartbeats. Researchers will implant a small heart monitor under the skin to watch for these heart rhythm problems. The goal is to learn how often these problems hap…

This early-phase study tests a small implantable device placed directly into liver tumors to see how they respond to cancer drugs. Ten adults with colorectal cancer that has spread to the liver will have the device inserted a few days before planned surgery to remove the tumor. T…

This early-phase study looks at how a non-invasive sound wave treatment called histotripsy affects the immune system in 12 people with colorectal cancer that has spread to the liver. Researchers will take blood samples before and after treatment to measure changes in immune T-cel…

This early-phase study tests a small device placed into pancreatic tumors during surgery to check how different drugs affect the cancer. Ten adults having their pancreas removed will receive the device, which is taken out with the tumor after about 4 hours. The main goal is to en…

This study is building a registry of up to 900 people with Diamond Blackfan anemia (DBA), a rare inherited bone marrow condition that causes low red blood cells. Researchers will collect medical information and genetic data to learn more about how DBA develops and affects patient…