Niguarda Hospital

This study tests if colchicine, a drug used for gout, can help people with chronic heart muscle inflammation (inflammatory cardiomyopathy). The goal is to see if it prevents worsening heart failure, dangerous heart rhythms, and damage seen on scans. About 80 adults with this cond…

This study looks at how safe and effective the EmboTrap II device is at removing blood clots in people having a severe stroke. About 100 participants will be watched to see if the device can restore blood flow to the brain without causing harm. The goal is to improve recovery by …

This study compares contrast-enhanced ultrasound (CEUS) to standard CT scans for detecting pseudoaneurysms (bulging blood vessel walls) in the spleen, liver, or kidneys after abdominal trauma. Researchers will enroll 385 adults with blunt or penetrating injuries to see if CEUS ca…

This study compares two ways to position patients during robot-assisted surgery to remove small kidney tumors. One is the standard side-lying position, and the other is a newer back-lying position. Researchers want to see which approach leads to fewer complications, cleaner tumor…

This study compares two breathing support methods for people with pneumonia who have low oxygen levels. One group gets alternating non-invasive ventilation and high-flow oxygen, while the other gets high-flow oxygen alone. The goal is to see which approach improves oxygen levels …

This study will follow 2500 people who had a TAVR procedure (a less invasive way to replace a heart valve) to understand their risks of bleeding or blood clots afterward. Researchers will track different blood thinner treatments and valve types to see how they affect these risks …

This study looks at 125 people who had a stroke with no clear cause and have mild-to-moderate heart muscle disease. Researchers will use advanced MRI or CT scans of the heart to find blood clots that standard ultrasound might miss. The goal is to see if better imaging can help do…

This study is looking at whether a blood test (called a liquid biopsy) can help doctors identify and track heart masses (tumors) without needing a surgical biopsy. Researchers will collect blood samples from 26 people aged 12 and older who have a heart mass, and compare the genet…

This study looks back at medical records of 5000 adults who had blunt chest or belly trauma to understand how often adrenal gland injury occurs and how it affects recovery. Researchers want to clarify conflicting reports about this rare injury. The goal is to learn more, not to t…

This study looks at a new way to place a heart valve (Navitor) during a procedure called TAVR. Normally, doctors try to align the valve carefully, but this can make it harder to reach the heart arteries later if needed. The study will test if randomly placing the valve makes it e…

This study is a registry that will collect information from about 3000 people hospitalized with cardiogenic shock, a life-threatening condition where the heart suddenly cannot pump enough blood. The goal is to better understand patient profiles, treatments, and outcomes over time…

This study looks at adults having appendix removal surgery to see if washing the belly with fluid (lavage) helps prevent infections after surgery. Researchers will track over 1,000 patients to compare infection rates based on how dirty the belly is during surgery. The goal is to …

This study looks at liver cancer tumors from 270 people to understand how the cancer avoids being attacked by the immune system. Researchers will analyze the genetic material in tumor samples to find new molecules that help cancer hide. The goal is to discover new targets for fut…

This study looks at 26 adults with severe heart failure and cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. Researchers will measure markers of inflammation and blood vessel damage over time to better understand how the body reacts during …

This study looks at whether a simple blood test (ctDNA) can help doctors decide which patients with metastatic colorectal cancer might benefit from retreatment with a targeted therapy called anti-EGFR. Researchers will collect and analyze data from 250 patients who have already h…

This study looks at how aging inside our cells may make heart disease worse. Researchers will measure DNA damage and other aging markers in 300 people with different types of chest pain or heart attacks. The goal is to find new ways to predict and treat dangerous plaque buildup i…

This study tests whether a dye called indocyanine green, which glows under a special camera, helps surgeons see and remove more lymph nodes during stomach cancer surgery. About 360 adults with advanced stomach cancer will take part. The goal is to see if the dye changes how the s…

This study looks at how much antibiotic is removed when ICU patients with septic shock and kidney failure receive blood-cleaning treatments. Twenty adults will have their antibiotic levels measured before and after the blood passes through the cleaning cartridges. The goal is to …

This study looks at how the bacteria in your gut might affect epilepsy that doesn't get better with standard medicines. Researchers will follow 120 people aged 3 to 50 who have drug-resistant epilepsy and are starting a new treatment like surgery or a special diet. By tracking ch…

This study looks at how well a treatment called ultrasound-assisted catheter-directed thrombolysis works for people with serious blood clots in the lungs (intermediate-high-risk pulmonary embolism). Researchers will track 180 participants for 6 months to see how many develop high…