National Cancer Centre, Singapore

This study tests a new, non-invasive treatment called histotripsy that uses sound waves to break down liver tumors. It involves 40 adults with liver cancer who cannot have surgery or other standard treatments. The goal is to see if it is safe and can control tumor growth.

This study tests if adding immunotherapy drugs (atezolizumab and bevacizumab) after targeted radiation therapy (SIRT-Y90) works better than radiation alone for people with advanced liver cancer that hasn't spread outside the liver. About 100 participants will be randomly assigned…

This study tests a one-year maintenance treatment combining tislelizumab (an immunotherapy) and low-dose capecitabine (a chemotherapy) in 53 adults with high-risk nasopharyngeal cancer. Participants have a specific marker (detectable EBV DNA) after initial chemotherapy, indicatin…

This study tests two drugs, pembrolizumab and olaparib, together in people with a rare type of blood cancer called peripheral T-cell lymphoma that has returned or not improved with prior therapy. The goal is to see if the combination can shrink or control the cancer. About 24 adu…

This study tests a combination of three drugs (pembrolizumab, lenvatinib, and letrozole) in 40 people with advanced hormone receptor-positive, HER2-negative breast cancer that has stopped responding to standard hormone therapy. The goal is to see if this combination can shrink tu…

This study tests a personalized vaccine made from a patient's own immune cells, combined with an immunotherapy drug (nivolumab), after surgery to remove liver cancer or colorectal cancer that spread to the liver. The goal is to see if this treatment can prevent the cancer from re…

This study tests whether a 24-week exercise program (aerobic and strength training, 3 times a week) can help prevent breast cancer from returning in people with early-stage breast cancer. About 2,156 participants who have completed surgery and any chemotherapy or radiation will t…

This study is testing a lung cancer screening program in Singapore using low-dose CT scans and blood tests. It will include 1,000 people at high risk, both smokers and non-smokers, to see if this approach is practical and accurate. The goal is to find lung cancer earlier and impr…

This study is testing a smartphone app called iCareBreast+ designed to help women with breast cancer manage the challenges of chemotherapy. The app provides self-care tools and information to boost confidence and knowledge about treatment. Researchers will enroll 40 women to see …

This study tests a program called ENABLE-SG that coaches people with advanced cancer and their family caregivers on how to cope better and avoid emergencies. The program is delivered by phone or video and starts soon after diagnosis, before serious problems arise. About 715 patie…

This study looks at whether exercise therapy and cognitive behavioral therapy (CBT) can reduce fatigue and improve treatment adherence in female breast cancer patients in Singapore. About 100 women who have completed surgery and chemotherapy will try these approaches. The goal is…

This study tests whether inhaling scents from Asian plants can reduce distress and anxiety in breast cancer patients before their first radiotherapy session. Researchers will measure changes in stress scores, anxiety levels, and stress hormones in 300 participants. The goal is to…

This study looks at the genetic makeup of tumors from 5,500 people with solid cancers. The goal is to use this information to match each person with the most suitable clinical trial or treatment. Participants must have a confirmed solid tumor and be able to provide a tissue sampl…

This study compares genetic counselling done by video (telegenetics) with in-person sessions for people at risk of hereditary breast, ovarian, or Lynch syndrome cancers. About 150 adults will be randomly assigned to one of the two methods. Researchers will measure how informed an…

This study looks at 50 adults with advanced solid tumors that no longer respond to standard treatments. Researchers will use genetic tests to match patients with experimental or off-label therapies, then track how well the tumors shrink and how patients feel. The goal is to creat…