Meyer Children's Hospital Irccs

This study tests whether a modified Atkins diet (a type of ketogenic diet) can help children and young adults with brain tumors lose weight. The tumors often damage the hypothalamus, leading to severe obesity that doesn't respond to standard diets or exercise. Researchers will en…

This study tests whether L-serine, a natural amino acid taken as a supplement, can improve overall functioning in children and young adults (ages 2-30) with GRIN-related neurodevelopmental disorders caused by certain gene variants. Each participant will receive both L-serine and …

This study tests whether applying a special skin glue (cyanoacrylate) around the IV site can keep the catheter in place better than the usual clear bandage alone. About 300 children visiting the emergency room who need an IV for at least 24 hours will be randomly assigned to get …

This study is investigating whether certain autoantibodies, especially those targeting a protein called nephrin, play a role in nephrotic syndrome, a kidney condition that causes swelling and protein loss in urine. Researchers will analyze blood and kidney tissue from 50 children…

This study looks at whether using lung ultrasound can help doctors avoid giving antibiotics to children who don't need them. About 659 children aged 3 to 10 with suspected pneumonia will be randomly assigned to get either standard care or care guided by lung ultrasound. The goal …

This study tracks 200 children in Italy with leishmaniasis, a parasitic infection that can affect the skin or internal organs. Researchers will look at how quickly the disease is diagnosed and treated, and how that affects recovery, relapse, and death rates. The goal is to identi…

This study is tracking 290 children with non-infectious chronic uveitis, a rare eye inflammation that can cause vision loss. Researchers will collect data on symptoms, lab results, and complications over several years. The goal is to better understand the disease and identify ris…

This study looks at 500 children with a rare birth defect affecting the anus and rectum. Researchers will compare different surgical techniques to see which one leads to better bowel control and fewer complications. The children will be followed for up to 6 years after surgery. T…

This study looks at how certain psychiatric drugs may change heart rhythms in children and teens. Researchers will track 100 young patients with eating disorders, mood disorders, or psychosis who are starting a new psychiatric medication. They will perform ECGs at the start and a…

This study is gathering information from 15 people with CACP syndrome, a rare genetic condition that causes joint problems and sometimes heart issues. Researchers want to better understand how the disease develops and changes over time. The goal is to improve diagnosis and care f…

This study looks at whether measuring infliximab levels in saliva is as good as measuring it in blood for children with inflammatory bowel disease (IBD). Fifteen children starting infliximab will provide saliva and blood samples during routine visits. The goal is purely to gather…

This study is observing up to 20 children diagnosed with juvenile eosinophilic fasciitis, a rare connective tissue disease. Researchers will track symptoms, lab results, and treatments over time to better understand the condition and improve future care. No new drugs or procedure…

This study aims to create a better way to predict long-term outcomes for people with Erdheim-Chester disease (ECD), a rare condition that causes abnormal cells to build up in bones and organs. Researchers will analyze data from 1000 patients to identify factors that affect surviv…

This study looks back at medical records of 60 newborns who had signs of possible intestinal blockage before birth. Researchers want to find out which ultrasound measurements best predict whether a baby will actually have a blockage after delivery. The goal is to help doctors giv…

This study looks at the bacteria and fungi in the gut and tumors of 100 children aged 3–18 who are suspected of having a brain tumor. Researchers want to see if changes in these microbes are linked to the tumor's presence or growth. The goal is to learn more, not to test a new tr…

This study tests a new, radiation-free ultrasound technology called REMS to measure bone density in children aged 5 to 18 who have conditions that weaken bones, such as brittle bone disease or osteoporosis. The goal is to see if REMS can work as well as the standard X-ray method …

This study aims to better understand pediatric brain tumors by analyzing tumor and blood samples from 50 children aged 3-18. Researchers will use advanced genetic tests and create 3D tumor models in the lab to see how different chemotherapy drugs affect the cells. The goal is to …

This observational study enrolls 500 children aged 6-17 who come to the emergency department with an acute asthma attack. Researchers will check if doctors follow the latest GINA 2025 guidelines for diagnosis, treatment, and follow-up. The goal is to see if standardizing care imp…

This study looks at why children with short bowel syndrome (a rare condition where part of the intestine is missing) respond differently to the drug teduglutide. Researchers will grow tiny, lab-made versions of the children's intestines (called organoids) from tissue samples take…

This study looks at people with rare changes in the COL4A1 or COL4A2 genes, which can cause bleeding in the brain and problems in other organs. Researchers will collect health information and blood samples from 120 people, including family members with and without the gene change…

This study looks at blood samples from children and adults with Behçet disease, as well as healthy children, to find biological markers that could improve diagnosis and monitoring. Researchers will analyze immune system signals, genetic material, and DNA changes. The goal is to b…

This study follows 150 cystic fibrosis patients starting the drug combination Trikafta (ETI) to see how it affects their metabolism, DNA methylation, and gut bacteria. Researchers will measure blood fats, sugars, and immune markers, and link them to drug levels. The goal is to un…

This study looks at two scoring tools (Kobayashi and Kawanet) to see if they can identify children with Kawasaki disease who are likely to resist standard IVIG treatment. About 10-20% of children don't respond to IVIG and face a higher risk of heart problems. Researchers will enr…

This study looks at how emotional awareness, attachment style, and thinking skills relate to physical symptoms like stomach pain or headaches in children. Researchers will assess 300 children with somatic symptom disorder using questionnaires and tests. The goal is to understand …