Meyer Children's Hospital Irccs

This study aims to improve how doctors diagnose a kidney condition called nephrotic syndrome in children. Researchers will use advanced blood tests and kidney tissue analysis to look for specific immune system markers (autoantibodies) that may cause the disease. By better underst…

This study tests whether adding a special skin glue around an IV site helps keep the IV in place better than the usual clear bandage alone. It involves 300 children up to 18 years old who need an IV for at least 24 hours in the emergency room. The goal is to reduce IV slips and a…

This study tests whether L-serine, a dietary supplement, can improve overall functioning in 40 children and young adults (ages 2-30) with GRIN-related neurodevelopmental disorders caused by specific gene variants. Each participant will receive both L-serine and a placebo in alter…

This study tests whether a ketogenic diet (modified Atkins diet) can help children and young adults aged 7-30 who have brain tumors and severe obesity due to hypothalamic damage. The goal is to see if at least 5% weight loss over 24 months is possible. The diet is already used fo…

This study gathers information from people with CACP syndrome, a rare inherited condition that causes finger stiffness, joint swelling, and sometimes heart lining inflammation. Researchers aim to better understand how the disease progresses and how it is currently managed. By col…

This study collects information from children diagnosed with juvenile-onset eosinophilic fasciitis, a rare disease that causes swelling and hardening of the skin and joints. Researchers aim to describe the symptoms, how the disease progresses, and how children respond to current …

This study looks at whether a new ultrasound technology called REMS can safely measure bone density in children aged 5 to 18 who have conditions that weaken bones, like osteoporosis or growth hormone deficiency. Unlike the current standard (DXA), REMS uses no radiation. The goal …

This study looks at why children with short bowel syndrome respond differently to the drug teduglutide. Researchers will grow mini-intestines (organoids) from tissue samples taken during routine surgery. They will then test the drug on these organoids in the lab to see how they c…

This study looks at tumor and blood samples from 50 children (ages 3-18) with brain tumors to find genetic changes and test how tumors respond to drugs using 3D lab models. The goal is to understand why some tumors resist treatment and pave the way for more personalized therapies…

This study looks at two scoring systems (Kobayashi and Kawanet) to see how well they predict which children with Kawasaki disease will not respond to the standard IVIG treatment. About 103 children from Europe and North India will be enrolled. The goal is to find out if these sco…

This study looks at children with Behçet disease, a rare condition that causes inflammation in blood vessels. Researchers will compare blood samples from children, adults with the disease, and healthy children to find biological markers that could help diagnose and track the dise…

This study is creating a new tool to predict long-term survival and disability in people with Erdheim-Chester disease (ECD), a rare condition that causes abnormal cells to build up in bones and organs. Researchers will analyze data from 1000 patients to identify factors like orga…

This study looks at people with rare changes in the COL4A1 or COL4A2 genes, which can cause bleeding in the brain and harm other organs like eyes, heart, and kidneys. Researchers will collect medical info and blood samples from 120 people, including family members with and withou…

This study looks at whether measuring infliximab (a biologic drug) in saliva can give similar results as measuring it in blood. It includes 15 children with inflammatory bowel disease starting infliximab. Saliva and leftover blood samples are collected during routine visits. The …

This study looks at stool samples from 100 children aged 3–18 who are suspected of having a brain tumor. Researchers want to see if changes in gut bacteria can help detect the tumor or track how the disease changes over time. The goal is to learn more, not to test a treatment.

This study looks at how well hospitals follow the latest GINA 2025 guidelines when treating children (ages 6-17) having an asthma attack. Researchers will check if using these guidelines leads to better diagnosis, treatment, and follow-up care. The goal is to improve care for chi…

This study looks at children under 18 with leishmaniasis, a parasitic infection that can affect the skin or internal organs. Researchers want to learn how delays in diagnosis and treatment affect recovery and death rates. By collecting data from hospitals across Italy, they hope …

This study looks at 500 children with a rare birth defect affecting the anus and rectum. Researchers will compare different surgical methods to see which one leads to better bowel control years later. The goal is to help doctors choose the best approach for each child.

This study looks at how children's ability to understand emotions, their attachment style, and thinking skills relate to physical symptoms like stomach pain or headaches with no clear medical cause. Researchers will assess 300 children to see if lower emotional awareness and inse…

This study looks at how certain psychiatric drugs affect the heart's electrical activity in children and teens. Researchers will track 100 young patients starting these medications, checking their ECGs at the start and after 3, 6, and 12 months. The goal is to find out how often …

This study reviews medical records of 60 newborns who had signs of possible intestinal blockage before birth. Researchers want to find out which ultrasound measurements best predict whether a baby will actually have a blockage after delivery. The goal is to help doctors give bett…

This study looks at how the cystic fibrosis drug combination ETI (elexacaftor-tezacaftor-ivacaftor) affects metabolism, gene activity, and gut bacteria in 150 people with CF. Researchers want to understand why some patients develop side effects like high cholesterol or obesity. T…

This study follows 290 children with a rare, long-term eye inflammation called non-infectious chronic uveitis. Researchers will track symptoms, lab results, and how well different treatments work over several years. The goal is to better understand the disease and find ways to pr…

This study looks at whether using lung ultrasound to diagnose pneumonia in children aged 3 to 10 can cut down on unnecessary antibiotic use. Currently, doctors often rely on exams and chest X-rays, which aren't always accurate. The goal is to see if ultrasound can guide better tr…