Major Extremity Trauma Research Consortium

This study tests whether a special gel, called PEG, can safely help repair damaged nerves in the arm after a serious injury. About 40 adults with a complete nerve injury will receive either standard surgery plus the gel or standard surgery alone. The goal is to see if the gel imp…

This study tests whether taking antibiotics by mouth for 6 weeks works as well as getting them through an IV for people with infected broken bones that didn't heal properly. About 250 adults will be randomly assigned to one of the two treatments, along with surgery. The goal is t…

This study tests whether a special vacuum dressing (negative pressure wound therapy) can reduce infections and other wound problems after surgery for high-risk leg fractures. About 352 adults with severe tibia fractures will be randomly assigned to get either the vacuum dressing …

This study tests whether injecting a person's own skin cells (from the palm) into the stump of a leg amputation can make the skin firmer and more comfortable for wearing a prosthetic. Twenty adults with below-knee amputations will receive either the cell injection or a placebo. T…