Major Extremity Trauma Research Consortium

This study tested whether giving patients extra oxygen during and after surgery could reduce the chance of surgical site infections after repair of severe leg fractures. Over 1,100 adults with high-energy tibia or ankle fractures took part. Researchers compared infection rates wi…

This study tested whether adding an extra antibiotic powder (tobramycin) to the standard antibiotic powder (vancomycin) during surgery could reduce deep infections in people with severe leg fractures. About 1,550 adults with high-risk tibia fractures were randomly assigned to rec…

This study tested a new type of physical therapy that also addresses thoughts and feelings (cognitive-behavioral therapy) to help people recover after a serious leg injury. The goal was to see if this program could improve physical function, reduce pain, and help people return to…

This study aimed to find proteins in the blood that could show early on whether a broken upper arm bone is healing correctly or might lead to a nonunion (failure to heal). Researchers enrolled 45 adults with isolated humerus fractures treated without surgery. They collected blood…

This study looked at 646 people with severe open leg fractures to understand if the types and amounts of bacteria in their wounds at the time of final closure could predict later deep infections. Researchers collected bacteria samples during surgery and tracked infections for up …

This study tested a new 'Mobility Toolkit' to see if it could easily and accurately measure how well people recover walking ability after serious leg fractures. About 244 adults aged 18-60 who had surgery for fractures of the shinbone, ankle, or heel bone took part. The goal was …