Jules Bordet Institute

This study is for people with advanced HER2-positive breast cancer whose disease has worsened after treatment with trastuzumab deruxtecan (T-DXd). Researchers will use a special PET scan (HER2-PET/CT) to see if the cancer still has HER2 targets. If the scan is positive, participa…

This study tests whether a highly focused type of radiation (SBRT) can better manage prostate cancer that returns after the prostate is removed, compared to usual treatments. About 284 men with a rising PSA after surgery will be randomly assigned to receive SBRT or standard care.…

This study compares two standard treatment approaches given before surgery for older adults (70+) with locally advanced rectal cancer. The goal is to see which approach helps people live longer and with fewer side effects. About 230 participants will be randomly assigned to one o…

This study tests whether precisely targeted radiation (SBRT) can extend the usefulness of current hormone therapy or CDK4/6 inhibitors in women with ER+/HER2- metastatic breast cancer that has started to progress in just 1-3 spots. Participants continue their existing medication …

This study tests whether giving testosterone every 15 days can improve quality of life in 20 men with low testosterone who are in palliative care and have no further treatment options. Participants receive injections of Sustanon 250 and complete questionnaires about symptoms and …

This study looks back at 500 patients who had extensive abdominal surgery for advanced cancers, sometimes with heated chemotherapy. The goal is to find out how often incisional hernias develop and what factors make them more likely. By identifying these risks, doctors hope to imp…

This study looks at whether a special scan can predict if men with advanced prostate cancer will respond to a targeted radiation treatment. About 110 men will get the treatment and have scans to measure the radiation dose to their tumors. The goal is to see if the dose can tell e…

This study is for people with solid tumors that have spread to the brain. Researchers want to collect data and samples (like blood and spinal fluid) from 600 participants to understand why and how brain metastases happen. The goal is to find better ways to treat or prevent them i…