Institut Bergonié

This study tests two drugs, pembrolizumab and cabozantinib, together in people with advanced sarcomas (cancers of the soft tissue or bone) that have not responded to standard treatments. The goal is to see if the combination can stop or shrink tumors for at least 6 months. About …

This study is testing whether adding an immune-boosting drug (BDB001) and targeted radiation to the immunotherapy atezolizumab can help control or shrink tumors in people with advanced solid tumors, including pancreatic, lung, bladder, and breast cancers. About 247 adults with th…

This Phase 3 trial is testing whether adding three extra cycles of chemotherapy before surgery can help prevent cancer spread in people with high-risk soft-tissue sarcoma. About 351 participants will be randomly assigned to standard treatment or standard treatment plus extra chem…

This study tests whether freezing a tumor (cryoablation) plus standard immunotherapy and chemotherapy helps people with advanced lung cancer live longer. About 214 participants will be randomly assigned to receive either the standard drug combination alone or with the freezing tr…

This study is for people with a certain type of prostate cancer that is not too advanced but has some higher-risk features. It tests whether adding a short course of the drug darolutamide to standard radiation therapy can lower PSA levels to a very low target (0.1 ng/mL or less) …

This study tests whether high-intensity focused ultrasound (HIFU) can destroy breast tumors without surgery. Fifteen women with small, early-stage breast cancers will receive HIFU before their planned surgery. The main goal is to see if the ultrasound completely kills the tumor c…

This study aims to analyze the genetic makeup of tumors from 10,000 adults with advanced solid tumors or blood cancers. By identifying specific genetic changes, doctors hope to match patients to targeted therapies in early-phase trials. The goal is to make cancer treatment more p…

This study is creating a large national database in France to collect medical and biological information from up to 150,000 people diagnosed with sarcoma, a rare type of cancer. The goal is to track how patients are treated and what happens to them over time, helping researchers …

This study looks at certain proteins called convertases in pancreatic tumor samples from 50 patients. Researchers want to see if the levels of these proteins are linked to the immune cells around the tumor. The goal is to find new ways to predict how the disease will progress, no…

This study is testing whether looking for tumor DNA in the blood can help predict if breast cancer will return in patients who had chemotherapy before surgery. Researchers will take blood samples over time from 180 people whose tumors did not fully disappear after chemo. The goal…

This study looks at how much radiation reaches tumors and healthy organs during a treatment called 177Lu-PSMA-617 for advanced prostate cancer that has spread. Researchers want to see if the radiation dose can predict how well the treatment works and what side effects might occur…

This study looks at whether adding a simple blood test that detects tumor DNA (ctDNA) to regular scans can help doctors choose better treatments for people with advanced colorectal or non-small cell lung cancer. About 332 adults with cancer that has spread will be randomly assign…

This study is developing artificial intelligence (AI) models to help pathologists classify and predict the behavior of rare uterine smooth muscle tumors, including those that are hard to diagnose (STUMP). Researchers will train the AI on digital images of tumor tissue from about …