Fondazione Irccs Ca' Granda, Ospedale Maggiore Policlinico

This study looks at how safe and effective daratumumab is for people with a rare blood clotting disorder called iTTP, especially when standard treatments have failed. About 40 adults who have already received daratumumab will be followed to see if their blood enzyme levels improv…

This study tests whether eye drops made from cord blood plasma can relieve moderate to severe dry eye better than standard artificial tears. Researchers will compare the two treatments in 100 adults over two months. The goal is to see if the cord blood drops improve eye surface d…

This study looks at whether a low-FODMAP diet can reduce pain and improve quality of life in women with endometriosis who also have stomach issues like bloating and constipation. About 150 women will either follow the diet or continue their usual care. The goal is to see if chang…

This observational study aims to understand how endothelial colony-forming cells (ECFCs) behave in people with von Willebrand disease (VWD) and acquired von Willebrand syndrome (AVWS) compared to healthy individuals. Researchers will collect blood samples from 48 participants to …

This study looks at 1,000 people with alcohol-related liver disease to understand how their genes and drinking habits together raise the risk of liver cancer. Researchers will analyze DNA and lifestyle factors to create a risk score that could help doctors decide who needs regula…

This study aims to understand why some people develop a rare, serious liver disease called primary sclerosing cholangitis (PSC). Researchers will create 3D cell models from patient samples to study how specific genetic changes affect bile duct cells. The goal is to find new ways …

This study looks at how the immune system responds to hepatitis D virus in patients also infected with hepatitis B. Researchers will measure immune cell activity before and after treatment with the drug bulevirtide. The goal is to better understand why some patients get worse fas…

This study is using advanced whole-genome sequencing to find hidden genetic causes of cholestatic liver disease in adults whose condition remains unexplained after standard tests. Researchers will compare the DNA of 60 affected adults to a large group of healthy controls. The goa…

This study gathers medical images and health data from 5000 people who had TEVAR (a type of aorta surgery) to create computer models called digital twins. These models simulate the surgery to help doctors choose the best device and predict problems. The goal is to make planning m…

This study uses tiny, lab-grown liver models (organoids) made from patient cells to understand how a specific gene variant (I148M of PNPLA3) contributes to non-alcoholic steatohepatitis (NASH), a serious fatty liver disease. Researchers will expose these mini-livers to fatty acid…

This study looks at how genetic factors influence the risk of liver damage and heart problems in people with fatty liver disease. Researchers will enroll 2,500 blood donors aged 40-65 who are overweight or have related conditions like high blood sugar or high cholesterol. The goa…

This study follows 650 women with endometriosis who want to have children after diagnosis. Researchers compare pregnancy rates and the need for fertility treatments between those who had surgery and those who took medication. The goal is to understand which approach leads to bett…

This study looks at whether using a mix of brain scans, spinal fluid tests, and thinking/movement assessments can better diagnose idiopathic normal pressure hydrocephalus (iNPH) and identify who will benefit from shunt surgery. Researchers will follow 116 adults aged 60+ with sus…

This study aims to create a rapid blood test that measures T-cell responses in people with chronic hepatitis B (HBV) or combined hepatitis B and D (HBV/HDV). Researchers will enroll 300 adults to see how these immune responses relate to disease severity and treatment outcomes. Th…

This study aims to see if a special cell culture system can detect a substance in the blood that causes protein leakage in the urine of people with a kidney condition called nephrotic syndrome. Researchers will compare blood and urine samples from 150 participants, including pati…