Eunice Kennedy Shriver National Institute Of Child Health And Human Development (nichd)

This study looked at how the diabetes drugs glyburide and metformin work in pregnant women with gestational diabetes. 177 women between 20 and 32 weeks pregnant took part. The goal was to find the right doses and understand how these drugs control blood sugar during pregnancy.

This study tested a daily injection called pegvisomant in 12 children aged 2 to 18 with gigantism, a condition causing too much growth hormone. The goal was to see if the drug could safely lower hormone levels and slow abnormal growth. Participants received the drug for 60 weeks …

This study tested whether colchicine, a common anti-inflammatory medicine, could improve metabolism in people with obesity who have high inflammation and high insulin levels but not yet high blood sugar. About 152 adults and teens took colchicine or a placebo daily for 12 weeks. …

This study looked at how lifestyle factors like diet and health habits affect a couple's ability to conceive. Researchers followed 266 couples planning their first pregnancy, tracking how long it took to get pregnant and whether early pregnancy loss occurred. The goal was to bett…

This study looked at people with suspected bone-related connective tissue disorders, like Osteogenesis Imperfecta and Melorheostosis, along with their healthy family members. The goal was not to test new treatments but to better understand these conditions through exams, scans, a…

This study looked at how depression changes the way mothers interact with their babies and how that affects the child's thinking, emotions, and development. About 700 English-speaking mothers (ages 20-45) with infants 4 months or younger took part in interviews, home video sessio…

This study looked at rare genetic disorders where the body cannot make cholesterol properly, which can cause birth defects and learning problems. Researchers collected blood, urine, and tissue samples from 342 participants, including patients and their family members, to better u…

This study tested two safe, light-based brain scanning methods (fNIRS and DCS) in children with rare neurocognitive disorders like Niemann-Pick disease and Smith-Lemli-Opitz syndrome, as well as healthy volunteers. The goal was to see if these scans could measure brain activity w…

This study enrolled 96 children of any age with known or suspected genetic disorders. The main goal was to give clinic staff hands-on experience and explore new research methods, not to provide treatment. Participants had medical exams, lab tests, and sometimes imaging or genetic…

This study looked at how obesity and related metabolic changes affect bone development in healthy girls aged 9 to 12. Researchers measured bone mass, density, and strength over two years. The goal is to understand risks and develop better prevention strategies for fractures and o…

This study followed 88 children and young adults with types III and IV osteogenesis imperfecta (brittle bone disease) to learn how the condition affects the body over time. Researchers tracked bone health, lung and heart function, hearing, and movement. The goal was to better und…

This study looks at adrenal gland tumors to understand why they form, why some make extra hormones, and why some turn into cancer. About 690 people aged 3 to 70 with known or suspected adrenal tumors will have tests like blood draws, urine collection, and imaging. The goal is to …

This study looked at people with rare conditions that cause hormone problems and tumors, like PPNAD and Carney Complex. Researchers aimed to find the genetic causes and link them to specific symptoms. Over 1,300 participants, including patients and their family members, were invo…

This study followed nearly 5,000 U.S. students starting in 10th grade for seven years to see how their health, habits, and risks changed over time. Researchers collected surveys, physical measurements, and genetic data to understand what influences positive behaviors like diet an…

This study looked at how a mother's age, whether she works, and if she has other children affect her interactions with her baby and the child's development. Researchers observed over 2,300 mothers and their children from 5 months to 4 years old. The goal was to understand how ear…

This study looked at Smith-Lemli-Opitz syndrome (SLOS), a rare genetic disorder that affects how the body makes cholesterol and causes birth defects and intellectual disabilities. Researchers studied 130 patients and their mothers to better understand the disease, its complicatio…

This study followed 46 children with osteogenesis imperfecta (OI), a condition that causes fragile bones and short stature, to understand how the disease progresses and how genes influence it. Participants had regular check-ups, scans, and tests over several years. No treatments …

This study looks at how early childhood relationships with caregivers influence the romantic partnerships people form as young adults. About 259 participants from an earlier child development study and their live-in partners will fill out online surveys about their relationships.…

This study tested a new technique called speckle plethysmography to see if it can measure blood pressure changes continuously using sensors on the fingers and toe. Forty healthy adults participated and underwent activities like slow breathing, math problems, and an ice bath to ch…

This study tested a noninvasive device that measures breathing, heart rate, body temperature, and oxygen levels. Researchers wanted to see if it could help screen and monitor respiratory infections like COVID-19. Forty healthy adults performed breathing tasks while the device was…