Centre Hospitalier Universitaire De Nīmes

Pancreatic and other biliopancreatic cancers often block the bile duct, causing jaundice and serious infections. Doctors use endoscopic procedures to place stents that restore bile flow, but several techniques exist and it is unclear which works best. This study follows 300 patie…

This study tests whether adding a special virus mixture (phage therapy) to standard wound care can shrink diabetic foot ulcers infected with staph bacteria more than standard care alone. About 60 adults with diabetes and a foot ulcer that has lasted over 2 weeks will take part. T…

This study tests whether a rapid test (multiplex PCR) combined with a treatment algorithm can help doctors choose the best antibiotics sooner for patients on ventilators who develop pneumonia. About 124 adults in intensive care will be randomly assigned to either the new strategy…

This study evaluates whether a French version of the HELP score can more accurately diagnose hyperemesis gravidarum (HG), a severe form of nausea and vomiting in pregnancy, compared to the standard PUQE score. Researchers will enroll 300 pregnant women experiencing nausea or vomi…

This study tests whether injecting botulinum toxin (like Botox) into the piriformis muscle can reduce pain and improve quality of life in people with piriformis muscle syndrome. About 108 adults who have had buttock or leg pain for at least 3 months and haven't gotten relief from…

This trial tests whether spinal manipulation (a hands-on therapy) can reduce pain within 7-10 days for people with acute or subacute low back pain. It will involve 416 adults who have had pain for less than 3 months. The study compares spinal manipulation to a control treatment (…

This study looks at whether leaving out bicarbonate from the numbing medicine (lidocaine with adrenaline) affects how well people recover the day after hand or foot surgery. About 150 adults having common procedures like carpal tunnel release or bunion surgery will be randomly as…

Some people with inflammatory bowel disease who take anti-TNF drugs develop painful rashes in skin folds and around the mouth, a condition called SPIDER. Researchers at a French hospital are studying whether levels of Staphylococcus aureus bacteria in these rashes change over six…

This study looks at whether a specialized support center called 'La Maison des Femmes' helps women who have experienced violence improve their quality of life. Researchers will follow 70 women in Nîmes, France, and measure their well-being using a standard questionnaire at the st…

This study examines the genetic makeup of carbapenem-resistant E. coli bacteria collected from patients in southern France. Researchers will sequence the bacteria's full genomes to identify different strains, resistance genes, and virulence factors. The goal is to understand how …

This study looks at whether working unusual hours or having long idle periods at work makes people more likely to develop problem gambling. Researchers will survey 1,600 employed adults in France who have gambled at least once in the past year. The goal is to understand how work …

This study will measure how much sevoflurane (an anesthesia gas) is used when ventilators are set to a very low fresh gas flow of 0.3 L/min. Researchers want to see if this ultra-low flow saves resources without affecting patient care. Data from 30 adult surgery patients will be …

This study surveys 200 healthcare professionals (doctors, nurses, and students) about how they remove breathing tubes after a patient has been on a ventilator. The goal is to describe which techniques are used most often, especially the use of positive pressure during removal. Th…

This study looks at the sticky layer of germs (biofilm) that forms on central venous catheters in intensive care patients. Researchers will measure how much biofilm builds up inside and outside the tube. The goal is to learn more about these infections so better prevention method…

This study looks at how people with a first episode of psychosis tell their life stories and whether that relates to their well-being and recovery. Researchers will compare 96 participants—those with early psychosis, those with chronic psychosis, and healthy controls—using questi…

This study will measure levels of lipoprotein A, a type of fat in the blood, in 300 people with stage 4 chronic kidney disease. Researchers want to see if high levels are linked to future heart attacks, strokes, or worsening kidney function over 18 months. The goal is to find a b…