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Spinal adjustment may offer fast back pain relief without drugs

NCT ID NCT07403500

Symptom relief Sponsor: Centre Hospitalier Universitaire de Nīmes Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This trial tests whether spinal manipulation (a hands-on therapy) can reduce pain within 7-10 days for people with acute or subacute low back pain. It will involve 416 adults who have had pain for less than 3 months. The study compares spinal manipulation to a control treatment (peripheral manipulation) to see which works better.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
spinal manipulation (a hands-on therapy to adjust the lower back)
What this could lead to
If it works, this could provide a safer, non-drug option for short-term low back pain relief.
What could go wrong
This is an early-stage trial with no blinding, so results may be biased. The expected benefit is small and only short-term (7-10 days).

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 416 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients seeking treatment for low back pain present for less than 3 months, with an average intensity greater than 50 on a visual analog scale of 0-100 in the previous 48 hours. * Patients able to complete online questionnaires. * Patients who have given their free and informed consent. * Patients who are affiliated with or beneficiaries of a health insurance plan. Exclusion Criteria: * Patients with a history of back surgery, undergoing corticosteroid or morphine treatment, with acute or chronic inflammatory diseases, with psychiatric illness, or with low back pain lasting more than 3 months. * Patients who have already undergone spinal manipulation for low back pain with the investigator. * Patients participating or having participated in a therapeutic or drug study in the 3 months prior to their inclusion in this protocol. * Patients in a period of exclusion determined by another study. * Patients under legal protection, guardianship, or conservatorship. * Patients unable to give their consent. * Patients for whom it is impossible to provide informed consent. * Pregnant or breastfeeding patients.

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Conditions

The condition(s) this trial relates to.

Bronchiolitis Obliterans Syndrome Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Back pain lower back chronic

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Nimes University Hospital

    Nîmes, Gard, 30029, France

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