Cambridge University Hospitals Nhs Foundation Trust

This study looks at whether limiting food intake to a 9-hour period each day can improve how the body uses insulin and manages blood sugar in people with obesity and prediabetes. Researchers will measure changes in insulin sensitivity, daily glucose control, and fat and muscle bi…

This study tests whether combining two drugs, pembrolizumab and olaparib, can shrink tumors in people with advanced pancreatic cancer that has a high number of genetic mutations. About 20 adults who have had no more than one prior treatment will receive the combination. The main …

This study tests whether powerful weight loss drugs can lower blood pressure in young adults (ages 18-40) who are overweight or obese and have early-stage hypertension. Participants will either receive standard care (medication and lifestyle advice) or a weight loss drug. The goa…

This study tests whether dapansutrile, a drug that targets inflammation, is safe and can reduce brain and body inflammation in people with early Parkinson's disease. 36 participants will take the drug or a placebo daily for 6 months, with brain scans and spinal fluid tests to mea…

This study looks at how people with vascular Ehlers-Danlos syndrome (vEDS), a rare genetic condition that weakens blood vessels, process and store fat. Researchers want to see if vEDS affects fat tissue, which could raise the risk of insulin resistance and diabetes. About 15 adul…

This study tests whether an AI tool can detect early signs of fluid buildup in the lungs by analyzing changes in a person's voice, cough, and breathing sounds. Researchers will enroll 250 adults with advanced heart failure to develop and refine the AI algorithm. The goal is to gi…