Boston Children's Hospital

This study is testing whether a special blended diet can reduce harmful bile acids in the stomachs of children who get most of their nutrition through a feeding tube. Researchers want to see if lowering these acids can help protect children from accidentally inhaling stomach cont…

This study is testing whether a 3-week treatment to reduce staph bacteria on the skin can help control eczema symptoms. Researchers will enroll 100 people with moderate-to-severe eczema to see if this bacterial reduction leads to less severe skin inflammation. Participants will u…

This study is testing if adding a drug called valproate to standard patching therapy can improve vision in children and teens (ages 8-17) with a 'lazy eye' (amblyopia) that hasn't fully gotten better with glasses or patching alone. The goal is to see if valproate, which may help …

This study aims to find out if installing a system to reduce radon gas in the home can help control asthma symptoms in children. It will involve 180 children with asthma who live in homes with radon. Researchers will compare a real radon reduction system to a fake one over 48 wee…

This study is testing a smartphone app called MyMedDiary to see if it helps children newly diagnosed with celiac disease. Researchers want to know if using the app makes it easier for families to stick to a strict gluten-free diet and learn which foods are safe. The study will in…

This early study is testing whether adding hydrogen gas to standard cooling therapy is safe and feasible for newborns with moderate-to-severe brain injury caused by oxygen deprivation during birth. The research will involve 54 infants who will receive either standard care alone o…

This study is testing whether a specific type of blended food, designed to bind bile acids, can help reduce hospital and emergency room visits for children with feeding tubes who are at risk for aspiration. It will compare this special diet to other standard feeding formulas over…

This study is testing a rapid bedside blood test, similar to a pregnancy test, to see if it can quickly and accurately tell if a child is having a specific type of stroke caused by a major blood clot. Researchers will enroll 250 children who arrive at the emergency room with sudd…

This study is testing whether using digital ear scopes instead of traditional ones helps pediatricians more accurately diagnose ear infections in young children. It involves 4 pediatric practices and will measure if the digital tool leads to fewer unnecessary antibiotic prescript…

This study tests a one-on-one training program for pediatricians to help them better prescribe HIV prevention medication (PrEP) to adolescents and young adults. Fifty doctors in the Boston area will receive the training to see if it's practical and acceptable, and if it changes h…

This study is testing a new educational program called CRUSH that teaches dating skills and sexual health to autistic adults. Researchers want to see if the 20-session group program with individual coaching is practical, well-received, and shows early signs of helping participant…

This study is testing whether everolimus, an existing FDA-approved medication, can safely improve social abilities in people with PTEN Hamartoma Tumor Syndrome (PHTS). About 60 children and adults with PHTS who experience social difficulties will take either everolimus or a place…

This study aims to find the best sedation approach for children aged 1-12 who need MRI scans. Researchers will test different doses of two sedative drugs (propofol and dexmedetomidine) to see which combinations provide safe, effective sedation with the quickest recovery times. Th…

This study is testing whether adding virtual reality (VR) to standard therapies can better help teenagers with long-lasting dizziness. Researchers think dizziness can be caused by the brain becoming overly reliant on visual cues. The VR headset will create controlled visual envir…

This study aims to find out which of two commonly used nerve pain medications works better for children and teenagers. Researchers will compare gabapentin and oxcarbazepine in 60 young patients with chronic nerve pain to see which reduces pain more effectively and has fewer side …

This study aims to see if giving a single dose of ketamine within the first hour of a sickle cell pain crisis can help patients avoid being admitted to the hospital. It will also check if starting ketamine early during a hospital stay reduces the need for strong opioid painkiller…

This study is testing whether mental skills training can help young athletes cope better with the stress of returning to sports after ACL knee surgery. It will enroll 130 athletes aged 8-25 who are having surgery at Boston Children's Hospital. Half will receive mental skills coac…

This study aims to find the best way to treat persistent knee pain in young female athletes. It will compare two treatments: a steroid injection and a placebo (saltwater) injection, both given alongside physical therapy. Researchers will measure which group has better pain relief…

This study aims to understand the health of the smallest blood vessels (microvasculature) in children undergoing surgery for Tetralogy of Fallot, a heart defect. Researchers will use a special handheld camera to take videos of these tiny vessels during and after surgery. The goal…

This study aims to understand if a single session of intense aerobic exercise can temporarily reduce pain sensitivity in young people, both with and without chronic pain conditions. Researchers will measure pain responses before and after exercise in 66 youth participants. The go…

This study aims to understand if certain proteins in the blood can signal brain injury in children and teenagers undergoing heart surgery. Researchers will measure these proteins in 100 patients under 18 years old who need surgery using a heart-lung machine. The goal is to find e…

This study is testing a handheld device that uses light to measure blood and oxygen levels in the heart and liver during complex heart surgeries on children. The goal is to see if this real-time information helps surgeons make better decisions during the operation, which could le…

This research study aims to understand if genetic factors contribute to neonatal encephalopathy, a brain disorder in newborns that can affect lifelong health. Researchers will analyze DNA from up to 300 children under 6 years old with this condition and their parents to look for …