Anrs, Emerging Infectious Diseases

This study is testing a new COVID-19 booster vaccine given as a nasal spray. Researchers want to see if it is safe and how well it triggers an immune response in the nose compared to the standard mRNA booster shot given in the arm. The trial will enroll 238 healthy adults in Fran…

This study is testing if using two antiviral drugs together works better than one alone, and if taking the main drug for 10 days is better than 5 days, for people with weakened immune systems who get COVID-19. It aims to help these high-risk patients clear the virus faster and mo…

This study is testing if adding a drug called adalimumab to the standard treatment can help more people survive a severe brain infection called tuberculosis meningitis when they also have HIV. It will involve 130 adults in Brazil, Mozambique, and Zambia who will receive either th…

This large, late-stage trial is testing if a new HIV drug combination (doravirine) works as well as a widely used current treatment (dolutegravir) for people starting therapy for the first time. It will enroll 610 adults across six countries and follow them for nearly two years. …

This study aims to understand how specific patterns of the human papillomavirus (HPV) are linked to the development of anal cancer or serious pre-cancerous growths over a 10-year period. It involves about 100 people in France who were previously in a related HIV prevention trial.…